加速度传感与比例积分微分控制的生化实现

Biochemical implementation of acceleration sensing and PIDA control.

作者信息

Alexis Emmanouil, Espinel-Ríos Sebastián, Kevrekidis Ioannis G, Avalos José L

机构信息

Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.

Commonwealth Scientific and Industrial Research Organisation (CSIRO), Clayton, VIC, Australia.

出版信息

NPJ Syst Biol Appl. 2025 Apr 26;11(1):39. doi: 10.1038/s41540-025-00514-0.

DOI:10.1038/s41540-025-00514-0

PMID:40287428

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12033284/

Abstract

This work introduces a realization of a proportional-integral-derivative-acceleration control scheme as a chemical reaction network governed by mass action kinetics. A central feature of this architecture is a speed and acceleration biosensing mechanism integrated into a feedback configuration. Our control scheme provides enhanced dynamic performance and robust steady-state tracking. In addition to our theoretical analysis, this is practically highlighted in-silico in both the deterministic and stochastic settings.

摘要

这项工作介绍了一种比例-积分-微分-加速度控制方案的实现，该方案作为一个由质量作用动力学控制的化学反应网络。这种架构的一个核心特征是集成到反馈配置中的速度和加速度生物传感机制。我们的控制方案提供了增强的动态性能和稳健的稳态跟踪。除了我们的理论分析之外，这在确定性和随机设置的计算机模拟中都得到了实际体现。