Aljuhani Manal
Radiological Science and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Front Aging Neurosci. 2025 Apr 14;17:1547185. doi: 10.3389/fnagi.2025.1547185. eCollection 2025.
Tumour necrosis factor- (TNF-) is a proinflammatory cytokine implicated in the regulation of innate and adaptive immunity. Two receptors exist for TNF-: TNF receptors 1 (TNFR-1) and 2 (TNFR-2). TNFR-1 and TNFR-2 have been reported to be involved in pleiotropic functions. Multiple lines of evidence implicate TNF- and its receptors as potential risk factors for Alzheimer's disease (AD). Studies are warranted to assess the association of TNF-, TNFR-1, and TNFR-2 with AD pathogenesis and whether they can serve as prognostic biomarkers indicative of AD.
In the present study, baseline levels of cerebrospinal fluid (CSF) TNF-, TNFR-1, and TNFR-2 were explored, and their potential as biomarkers to differentiate between individuals who remain stable and those who experience disease progression over 10 years in the Alzheimer's Disease Neuroimaging Initiative (ADNI) was assessed. The study also examined the correlation between baseline CSF proteins with established AD biomarkers, neuroimaging measures, and cognition.
Whilst the present study shows associations between baseline CSF levels of TNFs with AD biomarkers, the nature of the relationship is ambiguous.
The present study concludes that CSF TNFs do not serve as reliable or robust disease biomarkers of AD.
肿瘤坏死因子-α（TNF-α）是一种促炎细胞因子，参与先天性和适应性免疫的调节。TNF-α有两种受体：TNF受体1（TNFR-1）和2（TNFR-2）。据报道，TNFR-1和TNFR-2参与多种功能。多项证据表明，TNF-α及其受体是阿尔茨海默病（AD）的潜在危险因素。有必要开展研究以评估TNF-α、TNFR-1和TNFR-2与AD发病机制的关联，以及它们是否可作为AD的预后生物标志物。
在本研究中，我们探究了脑脊液（CSF）中TNF-α、TNFR-1和TNFR-2的基线水平，并评估了它们作为生物标志物在阿尔茨海默病神经影像学倡议（ADNI）中区分10年内病情保持稳定和病情进展患者的潜力。该研究还检查了基线CSF蛋白与已确立的AD生物标志物、神经影像学指标和认知之间的相关性。
虽然本研究显示了CSF中TNF水平基线与AD生物标志物之间的关联，但这种关系的性质尚不明确。
本研究得出结论，CSF中的TNF不能作为AD可靠或有力的疾病生物标志物。
