Wang Xuan, Zhang Xian K
Department of General Practice, Xiangya Hospital Central South University, and International Joint Research Center for Medical Metabolomics of Xiangya Hospital, Changsha 410008, China.
Department of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC 29403, USA.
Biomolecules. 2025 Mar 25;15(4):480. doi: 10.3390/biom15040480.
Friend leukemia virus integration 1 (Fli-1), a member of the ETS family of transcription factors, plays an essential role in diverse biological processes. Recent studies have underscored the significance of Fli-1 in modulating inflammation and autoimmune diseases via the regulation of inflammatory responses. Specifically, Fli-1 exerts control over inflammatory processes, influencing key effectors and signaling pathways associated with conditions such as systemic lupus erythematosus, scleroderma, cancer, and sepsis. This review aims to summarize the emerging roles of Fli-1 in inflammation and autoimmune diseases, with a focus on elucidating the underlying molecular mechanisms and exploring the potential therapeutic implications.
Friend白血病病毒整合1（Fli-1）是ETS转录因子家族的成员之一，在多种生物学过程中发挥着重要作用。最近的研究强调了Fli-1通过调节炎症反应在调节炎症和自身免疫性疾病中的重要性。具体而言，Fli-1对炎症过程发挥控制作用，影响与系统性红斑狼疮、硬皮病、癌症和败血症等病症相关的关键效应器和信号通路。本综述旨在总结Fli-1在炎症和自身免疫性疾病中新兴的作用，重点是阐明潜在的分子机制并探索潜在的治疗意义。
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