Mealy Joshua E, Torres William M, Freeburg Lisa A, Barlow Shayne C, Whalen Alison A, Maduka Chima V, Shazly Tarek M, Burdick Jason A, Spinale Francis G
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
College of Engineering and Computing, University of South Carolina, Columbia, South Carolina, USA; Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
JACC Basic Transl Sci. 2025 Apr;10(4):458-472. doi: 10.1016/j.jacbts.2024.11.009. Epub 2025 Jan 29.
Strategic delivery of hydrogels to the newly formed myocardial infarction (MI) is an area of active investigation and offers high target specificity for releasing a small molecule therapeutic payload. This study examined the effects of delayed post-MI delivery (pigs, 3 days post-MI) of a shear-thinning hydrogel which encapsulated and released a small molecule matrix metalloproteinase inhibitor. The results demonstrated the feasibility and efficacy of targeted delivery of a shear-thinning injectable hydrogel containing a small molecule matrix metalloproteinase inhibitor to attenuate post-MI remodeling.
将水凝胶战略性地递送至新形成的心肌梗死（MI）区域是一个正在积极研究的领域，它为释放小分子治疗药物提供了高靶向特异性。本研究考察了在心肌梗死后3天（猪）延迟递送一种包封并释放小分子基质金属蛋白酶抑制剂的剪切稀化水凝胶的效果。结果证明了靶向递送含小分子基质金属蛋白酶抑制剂的剪切稀化可注射水凝胶以减轻心肌梗死后重塑的可行性和有效性。
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