Tian Lv, Wen Yixuan, Li Tao, Liu Chuanwang, Fan Jun
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Shimmer Center, Tianfu Jiangxi Laboratory, Chengdu, Sichuan, China.
Ann Med. 2025 Dec;57(1):2499027. doi: 10.1080/07853890.2025.2499027. Epub 2025 May 6.
Application-based interventions have gradually emerged as potential tools for improving the health status of cancer patients. However, the conclusions of existing studies on the effectiveness of app-based intervention in managing breast cancer symptoms vary.
This study systematically searched the PubMed, Web of Science, Scopus, Cochrane Library, and EMBASE databases from the inception of each database to October 25, 2024. Two researchers independently screened studies, extracted data, and evaluated the quality using the Cochrane Risk of Bias Tool. Data analysis was performed using RevMan 5.3 software, and the effect size was expressed as the standardized mean difference (SMD).
Of 16 included randomized controlled trials, meta-analysis results indicated that, compared to usual care, app-based interventions significantly improved breast cancer patients' quality of life (14 studies, SMD = 0.84, 95%CI = 0.48 - 1.19, < 0.00005, I = 90%, GRADE = low), and positively alleviated physical pain and anxiety (5 studies, SMD = - 0.60, 95%CI = -0.92 to -0.29, = 0.0002, I= 56%, GRADE = very low; 3 studies, SMD = -0.75, 95% CI = -1.40 to -0.09, = 0.03, I= 86%, GRADE = very low). However, no statistically significant differences were observed in improving fatigue (3 studies, SMD = 0.18, 95%CI = - 0.05 - 0.42, = 0.13, I = 0%) and depression (2 studies, SMD = -0.65, 95%CI = - 2.12 - 0.82, = 0.38, I = 96%).
Application-based interventions can significantly improve the quality of life of breast cancer patients, effectively relieve pain, and reduce anxiety.
基于应用程序的干预措施已逐渐成为改善癌症患者健康状况的潜在工具。然而，现有关于基于应用程序的干预措施在管理乳腺癌症状有效性的研究结论各不相同。
本研究系统检索了从各数据库建库至2024年10月25日的PubMed、Web of Science、Scopus、Cochrane图书馆和EMBASE数据库。两名研究人员独立筛选研究、提取数据，并使用Cochrane偏倚风险工具评估质量。使用RevMan 5.3软件进行数据分析，效应大小以标准化均数差（SMD）表示。
在纳入的16项随机对照试验中，荟萃分析结果表明，与常规护理相比，基于应用程序的干预措施显著改善了乳腺癌患者的生活质量（14项研究，SMD = 0.84，95%CI = 0.48 - 1.19，< 0.00005，I² = 90%，GRADE = 低），并积极缓解了身体疼痛和焦虑（5项研究，SMD = -0.60，95%CI = -0.92至-0.29，P = 0.0002，I² = 56%，GRADE = 极低；3项研究，SMD = -0.75，95%CI = -1.40至-0.09，P = 0.03，I² = 86%，GRADE = 极低）。然而，在改善疲劳（3项研究，SMD = 0.18，95%CI = -0.05 - 0.42，P = 0.13，I² = 0%）和抑郁（2项研究，SMD = -0.65，95%CI = -2.12 - 0.82，P = 0.38，I² = 96%）方面未观察到统计学显著差异。
基于应用程序的干预措施可显著改善乳腺癌患者的生活质量，有效缓解疼痛，并减轻焦虑。
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