基于I型胶原蛋白的水凝胶综述：聚焦组成-结构-性能关系
Review of collagen type I-based hydrogels: focus on composition-structure-properties relationships.
作者信息
Pires Figueiredo Mariana, Rodríguez-Fernández Silvia, Copes Francesco, Mantovani Diego
机构信息
Laboratory for Biomaterials and Bioengineering, Canada Research Chair Tier I for the Innovation in Surgery, Department of Min-Met-Materials Engineering and Regenerative Medicine, CHU de Quebec Research Center, Laval University, Quebec City, QC Canada.
出版信息
NPJ Biomed Innov. 2025;2(1):16. doi: 10.1038/s44385-025-00018-w. Epub 2025 May 3.
This review explores each stage of Collagen type I (Coll-I) hydrogel development, highlighting how sourcing, extraction, solubilization, and modification (e.g, blending, crosslinking, and composite formation) influence its gelation, and structural, mechanical, and biological properties. By clarifying key interrelations among these characteristics, this work serves as a valuable guide for scientists designing next-generation of Coll-I-based hydrogels with optimized properties for tissue engineering and regenerative medicine applications.
本综述探讨了I型胶原蛋白（Coll-I）水凝胶开发的每个阶段，强调了其来源、提取、溶解和改性（如共混、交联和复合材料形成）如何影响其凝胶化以及结构、力学和生物学特性。通过阐明这些特性之间的关键相互关系，这项工作为科学家设计具有优化性能的下一代基于Coll-I的水凝胶提供了有价值的指导，以用于组织工程和再生医学应用。
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