Fujikawa Shingu Kei, Waguri Masako, Takahara Mitsuyoshi, Katakami Naoto, Shimomura Iichiro
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Obstetric Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.
J Diabetes Investig. 2025 Jul;16(7):1325-1328. doi: 10.1111/jdi.70045. Epub 2025 May 8.
Overt diabetes in pregnancy (ODP) was originally included in gestational diabetes mellitus, which was positioned between normal glucose tolerance and pre-existing diabetes mellitus (PDM) in perinatal risk. This retrospective study aimed to clarify the differences between women with ODP and those with PDM. Compared with women with PDM (n = 162), those with ODP (n = 76) had higher HbA1c levels especially in the first trimester (8.2 ± 1.5% vs 7.2 ± 1.5%; P < 0.001). Furthermore, women with ODP had higher pre-pregnancy body mass index (30.8 ± 7.0 vs 28.5 ± 5.6 kg/m; P = 0.010), and a higher incidence of congenital anomalies (19.7% vs 9.3%; P = 0.035). In conclusion, ODP was not milder than PDM; women with ODP did not only have poorer glycemic control but also had poorer pre-pregnant weight control. Their burdens could be relieved through appropriate management before pregnancy.
妊娠显性糖尿病（ODP）最初被纳入妊娠期糖尿病，其在围产期风险方面介于正常糖耐量和孕前糖尿病（PDM）之间。这项回顾性研究旨在阐明ODP女性与PDM女性之间的差异。与PDM女性（n = 162）相比，ODP女性（n = 76）的糖化血红蛋白（HbA1c）水平更高，尤其是在孕早期（8.2±1.5%对7.2±1.5%；P < 0.001）。此外，ODP女性孕前体重指数更高（30.8±7.0对28.5±5.6kg/m²；P = 0.010），先天性异常的发生率也更高（19.7%对9.3%；P = 0.035）。总之，ODP并不比PDM病情轻；ODP女性不仅血糖控制较差，孕前体重控制也较差。通过孕前适当管理可以减轻她们的负担。
