光果甘草多糖通过保护肠道屏障完整性改善葡聚糖硫酸钠诱导的结肠炎。
Glycyrrhiza pallidiflora Polysaccharide Ameliorates DSS-Induced Colitis by Protecting Intestinal Barrier Integrity.
作者信息
Zeng Dandan, Ren Weijie, Zhao Bo, Li Yuanyuan, Jiao Jinlong, Mo Tianlu
机构信息
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
出版信息
Cell Biochem Biophys. 2025 May 9. doi: 10.1007/s12013-025-01765-8.
Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease. Glycyrrhiza pallidiflora polysaccharide (GPP) is an important constituent of a species of Glycyrrhiza pallidiflora, but its therapeutic mechanism in UC mice is not clear. A dextran sulphate sodium salt (DSS)-induced mouse model of UC was established, and GPP was extracted by ultrasound-assisted extraction, optimised to a GPP content of 25.66% by one-factor optimisation. The effects of different doses (100, 200, 300 mg/kg) of GPP on UC were investigated. The results showed that GPP could delay the trend of weight loss, reduce the DAI score and decrease colon damage in mice, and GPP had a better ameliorative effect on enteritis, which provided a theoretical basis for studying the effect of natural products on UC.
溃疡性结肠炎（UC）是一种特发性炎症性肠病。光果甘草多糖（GPP）是光果甘草的一种重要成分，但其在UC小鼠中的治疗机制尚不清楚。建立了葡聚糖硫酸钠（DSS）诱导的UC小鼠模型，并采用超声辅助提取法提取GPP，通过单因素优化将GPP含量优化至25.66%。研究了不同剂量（100、200、300mg/kg）的GPP对UC的影响。结果表明，GPP可延缓小鼠体重减轻趋势，降低疾病活动指数（DAI）评分，减轻结肠损伤，且GPP对肠炎有较好的改善作用，为研究天然产物对UC的作用提供了理论依据。
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