Rimsky Elizabeth R, Sattarzadeh Aysan, Jia Kaiyu, Khan Shahkar, Khan Danyal, Amor Martin, Spagnola Jonathan
Department of Medicine, Northwell at Staten Island University Hospital, Staten Island, USA.
Department of Cardiology, Northwell at Staten Island University Hospital, Staten Island, USA.
Eur J Case Rep Intern Med. 2025 Apr 23;12(5):005357. doi: 10.12890/2025_005357. eCollection 2025.
The Gerbode defect is a rare cardiac anomaly characterised by abnormal communication between the left ventricle and right atrium. Although primarily congenital, it can also be acquired, typically as a complication of myocardial infarction or infective endocarditis. This report examines a unique case of multivalvular infective endocarditis caused by group B Streptococcal bacteraemia, which led to the development of an acquired Gerbode defect.
A 64-year-old male patient presented with symptoms of fever and dyspnoea and was diagnosed with group B Streptococcal bacteraemia. Transoesophageal echocardiography (TOE) and cardiac magnetic resonance were used to assess the extent of valvular involvement and detect any underlying structural abnormalities. Comprehensive clinical, microbiological and imaging evaluations were performed to confirm the diagnosis.
A transthoracic echocardiography revealed multivalvular vegetations and a newly detected left ventricle-to-right atrium shunt, consistent with a Gerbode defect. Cardiovascular magnetic resonance imaging confirmed the acquired defect. Surgery was considered but deemed too high a risk due to the likelihood of postoperative dialysis and a greater than 50% morality risk. After discussing these risks, the patient and family opted for conservative management, and palliative care was initiated.
This case highlights the rare development of an acquired Gerbode defect in the context of multivalvular infective endocarditis due to group B Streptococcus. Early diagnosis using advanced imaging techniques is critical for proper management. Surgical intervention remains a key therapeutic option, and a multidisciplinary approach is essential for optimising patient outcomes in such complex cases.
An acquired Gerbode defect (left ventricular to right atrial shunt) is a rare but critical complication of infective endocarditis.Infective endocarditis caused by group B in adults, though uncommon, carries a high risk of complications and mortality, especially in prosthetic valve patients.Early transoesophageal echocardiography is essential for identifying structural complications of infective endocarditis.
Gerbode缺损是一种罕见的心脏异常,其特征为左心室与右心房之间存在异常交通。虽然主要为先天性,但也可能是后天获得性的,通常是心肌梗死或感染性心内膜炎的并发症。本报告探讨了一例由B组链球菌菌血症引起的多瓣膜感染性心内膜炎的独特病例,该病例导致了后天性Gerbode缺损的形成。
一名64岁男性患者出现发热和呼吸困难症状,被诊断为B组链球菌菌血症。经食管超声心动图(TOE)和心脏磁共振成像用于评估瓣膜受累程度并检测任何潜在的结构异常。进行了全面的临床、微生物学和影像学评估以确诊。
经胸超声心动图显示多瓣膜赘生物以及新发现的左心室至右心房分流,符合Gerbode缺损。心血管磁共振成像证实了后天性缺损。考虑进行手术,但由于术后透析的可能性以及超过50%的死亡风险,认为风险过高。在讨论这些风险后,患者及其家属选择了保守治疗,并开始了姑息治疗。
本病例突出了在B组链球菌引起的多瓣膜感染性心内膜炎背景下后天性Gerbode缺损的罕见发生情况。使用先进成像技术进行早期诊断对于正确管理至关重要。手术干预仍然是关键的治疗选择,多学科方法对于优化此类复杂病例的患者预后至关重要。
后天性Gerbode缺损(左心室至右心房分流)是感染性心内膜炎罕见但严重的并发症。成人中由B组链球菌引起的感染性心内膜炎虽然不常见,但并发症和死亡率风险很高,尤其是在人工瓣膜患者中。早期经食管超声心动图对于识别感染性心内膜炎的结构并发症至关重要。