Park Su-Jeong, Kim Mee Kyung, Kim Jinyoung, Choi Ji-Yeon, Song YoonJu, Kwon Hyuk-Sang
Department of Food Science and Nutrition, The Catholic University of Korea, Bucheon-si 14662, Republic of Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea.
Nutrients. 2025 Apr 30;17(9):1530. doi: 10.3390/nu17091530.
: Calorie restriction is increasingly recognized as a strategy for glycemic management in type 2 diabetes mellitus (DM) by promoting weight loss and potentially achieving diabetes remission. This study evaluated the feasibility of a 12-week structured calorie-restricted dietary intervention based on healthy Korean dietary patterns for adults with early type 2 DM. : Adults aged 18-60 years with a body mass index (BMI) greater than 25 kg/m and a short duration of diabetes were recruited. The intervention comprised two phases: a 6-week weight loss phase, targeting a 3% reduction every two weeks, starting with an 800 kcal/day diet and increasing by 200 kcal per phase, with all meals provided via home delivery, followed by a 6-week self-managed weight maintenance period, preceded by a one-week reintroduction phase with meals provided. : Among 27 participants, 24 completed the intervention (89% retention). Mean weight reduction at 6 weeks was 6.4 kg (7.6%), primarily achieved during Phase 1 (5.1%). By 12 weeks, the average weight reduction further improved to 7.4 kg (8.7%). Dietary adherence ranged from 80% to 90%, with energy intake closely aligning with the prescribed targets. Non-achievers exhibited a smaller initial reduction (2.5 kg vs. 3.9 kg), with the gap persisting throughout the study. Postprandial glycemic response to a mixed meal (65% carbohydrate) significantly improved from baseline to week 5. : This structured dietary intervention demonstrated substantial weight reduction and improved glycemic response in adults with type 2 DM, highlighting its feasibility and effectiveness as a guided strategy for weight management.
热量限制作为2型糖尿病(DM)血糖管理的一种策略,越来越受到认可,因为它能促进体重减轻,并有可能实现糖尿病缓解。本研究评估了基于韩国健康饮食模式,对患有早期2型糖尿病的成年人进行为期12周的结构化热量限制饮食干预的可行性。招募了年龄在18 - 60岁、体重指数(BMI)大于25 kg/m²且糖尿病病程较短的成年人。干预包括两个阶段:一个为期6周的体重减轻阶段,目标是每两周减少3%,从每天800千卡的饮食开始,每个阶段增加200千卡,所有餐食通过家庭配送提供,随后是一个为期6周的自我管理体重维持期,在此之前有一个为期一周的重新引入阶段,期间提供餐食。在27名参与者中,24人完成了干预(保留率89%)。6周时平均体重减轻6.4千克(7.6%),主要在第一阶段实现(5.1%)。到12周时,平均体重减轻进一步改善至7.4千克(8.7%)。饮食依从性在80%至90%之间,能量摄入与规定目标紧密相符。未达到目标者最初体重减轻较少(2.5千克对3.9千克),且在整个研究过程中差距持续存在。从基线到第5周,对混合餐(碳水化合物含量65%)的餐后血糖反应显著改善。这种结构化饮食干预在2型糖尿病成年人中显示出显著的体重减轻和改善的血糖反应,突出了其作为体重管理指导策略的可行性和有效性。