罗马尼亚西北部的结肠息肉：一项关于内镜和病理特征的单中心综合分析

Colonic polyps in North-Western Romania: a comprehensive single-center analysis of endoscopic and pathological features.

作者信息

Albu Andrada, Baroana Cosmin I, Farcas Radu A, Friedrich Eduard, Ismaiel Abdulrahman, Dumitrascu Dan L, Grad Simona

机构信息

2 Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

出版信息

Med Pharm Rep. 2025 Apr;98(2):183-189. doi: 10.15386/mpr-2742. Epub 2025 Apr 29.

DOI:10.15386/mpr-2742

PMID:40371405

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12070969/

Abstract

BACKGROUND AND AIMS

Most colorectal cancers (CRC) originate from precancerous adenomatous and serrated lesions. Accepted risk determinants for conventional adenomas and CRC include age, male gender and familial history. The aim of our study was to outline the characteristics of colorectal polyps in our center, as well as to uncover associations between them and certain clinical presentations.

METHODS

We retrospectively collected the data available in a tertiary center of the patients that underwent colonoscopy for various indications (e.g.: rectorrhagia, abdominal pain, screening, anemia etc.) between the 1 of January 2022 and the 1 of August 2023. We analyzed the age, gender and symptoms of the patients. We analyzed the colorectal polyps detected. We classified the polyps based on location, size, shape, architecture and dysplasia grade. Statistical analysis was conducted to evaluate potential associations between their characteristics.

RESULTS

248 subjects were identified and included in the study. There were 584 polyps uncovered during the colonoscopies in 248 subjects. 498 polyps were excised and retrieved; 44.5% were right-sided and 55.5% were left-sided. Most of the polyps were < 1 cm (78.2%). There were significantly more adenomatous polyps (68.8%) than non-adenomatous (31.2%). Most of the polyps had a low grade of dysplasia (59.8%). There were significant associations between the polyp size and dysplasia grade, number and location on the transverse colon. Polyps under 1 cm were more likely to be tubular (p=0.008). The age of the patients >50 years was associated with a greater number of polyps (p=0.002). There was a moderate statistically significant association (p=0.0297) between the male gender and the number of adenomatous polyps.

CONCLUSIONS

Male gender, age greater than 50 years, history of colorectal polyps are risk factors for the development of colorectal polyps in the studied population. A history of more than 2 polyps and a size greater of 1 cm can be associated with higher rates of dysplasia.

摘要

背景与目的

大多数结直肠癌（CRC）起源于癌前腺瘤性和锯齿状病变。公认的传统腺瘤和CRC的风险决定因素包括年龄、男性性别和家族史。我们研究的目的是概述我们中心结直肠息肉的特征，并揭示它们与某些临床表现之间的关联。

方法

我们回顾性收集了2022年1月1日至2023年8月1日期间在一家三级中心因各种适应证（如：直肠出血、腹痛、筛查、贫血等）接受结肠镜检查的患者的可用数据。我们分析了患者的年龄、性别和症状。我们分析了检测到的结直肠息肉。我们根据息肉的位置、大小、形状、结构和发育异常程度进行分类。进行统计分析以评估其特征之间的潜在关联。

结果

共确定248名受试者并纳入研究。在248名受试者的结肠镜检查中发现了584个息肉。切除并取回498个息肉；44.5%位于右侧，55.5%位于左侧。大多数息肉<1 cm（78.2%）。腺瘤性息肉（68.8%）明显多于非腺瘤性息肉（31.2%）。大多数息肉发育异常程度低（59.8%）。息肉大小与发育异常程度、数量及横结肠位置之间存在显著关联。<1 cm的息肉更可能为管状（p = 0.008）。年龄>50岁的患者息肉数量更多（p = 0.002）。男性性别与腺瘤性息肉数量之间存在中度统计学显著关联（p = 0.0297）。