Hong Suk-Min, Choi Chang-Hoon, Felder Jörg, Shah N Jon
Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.
Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, Jülich, Germany.
Med Phys. 2025 Jul;52(7):e17890. doi: 10.1002/mp.17890. Epub 2025 May 19.
Fluorine-19 (F) magnetic resonance imaging (MRI) is a non-invasive imaging tool for the targeted application of fluorinated agents, such as cell tracking, and for the demonstration of oximetry. However, as the SNR of F is significantly weaker than that of proton (H) imaging, the F coil must be combined with H coils for anatomical co-registration and B shimming. This is difficult due to the strong coupling between the coils when they are in proximity, and is problematic since the Larmor frequency of F is 94% that of H, further increasing the potential for coupling between the H and F elements.
Conventional double-tuned coil methods tend to generate loss compared to single-tuned reference coils. The asymmetrical butterfly coil has a split resonance peak, which can cover frequencies of H and F without losses arising from lossy traps or switching circuits. In this study, the use of an asymmetrical butterfly coil was evaluated for H/F applications.
To increase quadrature efficiency at both the H and F frequencies, the left and right loops of the butterfly coil were tuned asymmetrically. The coil's tuning and performance were evaluated in simulations and MR measurements, and the results were compared to a dimension-matched single-tuned loop coil.
The split resonance peak of the asymmetrical butterfly coil successfully spanned the F to H frequency. It operated with higher quadrature efficiency at both H and F frequencies and demonstrated superior receive sensitivity and SNR compared to the dimension-matched single-tuned loop coil.
The split resonance peak of the asymmetrical butterfly coil supported both H and F frequencies, delivering a higher SNR than that of the single-tuned loop coil. Since the asymmetrical butterfly coil can cover ¹H and ¹⁹F frequencies without loss and provides higher efficiency than the reference single-tuned coil, it can be effectively utilized for ¹H/¹⁹F MRI applications.
氟 - 19(F)磁共振成像(MRI)是一种用于靶向应用氟化剂(如细胞追踪)以及血氧测定的非侵入性成像工具。然而,由于F的信噪比明显低于质子(H)成像,F线圈必须与H线圈结合以进行解剖学配准和B场匀场。当线圈靠近时,由于它们之间的强耦合,这变得很困难,并且存在问题,因为F的拉莫尔频率是H的94%,这进一步增加了H和F元件之间耦合的可能性。
与单通道参考线圈相比,传统的双调谐线圈方法往往会产生损耗。非对称蝶形线圈具有分裂共振峰,可覆盖H和F的频率,而不会因有损陷波器或开关电路产生损耗。在本研究中,评估了非对称蝶形线圈在H/F应用中的使用情况。
为了提高H和F频率下的正交效率,蝶形线圈的左右回路进行了不对称调谐。通过模拟和磁共振测量对线圈的调谐和性能进行了评估,并将结果与尺寸匹配的单通道环形线圈进行了比较。
非对称蝶形线圈的分裂共振峰成功跨越了F到H的频率。它在H和F频率下均以更高的正交效率运行,并且与尺寸匹配的单通道环形线圈相比,显示出更高的接收灵敏度和信噪比。
非对称蝶形线圈的分裂共振峰支持H和F频率,提供了比单通道环形线圈更高的信噪比。由于非对称蝶形线圈可以无损耗地覆盖¹H和¹⁹F频率,并且比参考单通道线圈具有更高的效率,因此它可以有效地用于¹H/¹⁹F MRI应用。