链激酶及其他纤溶酶原激活剂与纤溶酶原和纤维蛋白相互作用的动力学研究。
Kinetic studies on the interaction of streptokinase and other plasminogen activators with plasminogen and fibrin.
作者信息
Fears R, Hibbs M J, Smith R A
出版信息
Biochem J. 1985 Jul 15;229(2):555-8. doi: 10.1042/bj2290555.
Abstract
The activation of Lys-plasminogen to plasmin by streptokinase was promoted by soluble fibrin such that Km was decreased and Vmax. increased. Enhancement was also observed when Glu-plasminogen was the substrate and was shared by the preformed streptokinase-plasminogen activator complex, indicating that the stimulation was not exerted primarily on the rate of active site formation.
摘要
可溶性纤维蛋白可促进链激酶将赖氨酸纤溶酶原激活为纤溶酶，从而使米氏常数（Km）降低，最大反应速度（Vmax）增加。当以谷氨酸纤溶酶原为底物时也观察到增强作用，且这种增强作用由预先形成的链激酶 - 纤溶酶原激活剂复合物共同介导，这表明该刺激作用并非主要作用于活性位点的形成速率。
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