验证运动校正后的图像与传统MPRAGE图像在儿科形态学分析中的一致性。
Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis.
作者信息
Gal-Er Barat, Brackenier Yannick, Bonthrone Alexandra F, Casella Chiara, Price Anthony, Arulkumaran Sophie, Chew Andrew T M, Nosarti Chiara, Cleri Michela, Cio Pierluigi Di, Egloff Alexia, Rutherford Mary A, O'Muircheartaigh Jonathan, Tomi-Tricot Raphael, Malik Shaihan, Cordero-Grande Lucilio, Hajnal Joseph V, Counsell Serena J
机构信息
Centre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Research Department of Imaging Physics and Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
出版信息
Front Neurosci. 2025 May 9;19:1534924. doi: 10.3389/fnins.2025.1534924. eCollection 2025.
PURPOSE
This study aimed to validate a retrospective motion correction technique, Distributed and Incoherent Sample Orders for Reconstruction Deblurring using Encoding Redundancy (DISORDER), for pediatric brain morphometry.
METHODS
Two T1-weighted MPRAGE 3D datasets were acquired at 3 T in thirty-seven children aged 7-8 years: one with conventional linear phase encoding and one using DISORDER. MPRAGE images were scored as motion-free or motion-corrupt. Cortical morphometry and regional brain volumes were measured with FreeSurfer, subcortical grey matter (GM) with FSL-FIRST, and hippocampi with HippUnfold. Intraclass correlation coefficient (ICC) was used to determine agreement. Mann-Whitney was used to test the difference between measures obtained using DISORDER and (i) motion-free and (ii) motion-corrupt conventional MPRAGE data.
RESULTS
ICC measures between conventional MPRAGE and DISORDER data were good/excellent for most subcortical GM (motion-free, 0.75-0.96; motion-corrupt, 0.62-0.98) and regional brain volumes (motion-free 0.47-0.99; motion-corrupt, 0.54-0.99), except for the amygdala and nucleus accumbens (motion-free, 0.38-0.65; motion-corrupt, 0.1-0.42). These values were less consistent for motion-corrupt conventional MPRAGE data for hippocampal volumes (motion-free 0.65-0.99; motion-corrupt, 0.11-0.91) and cortical measures (motion-free 0.76-0.98; motion-corrupt, 0.09-0.74). Mann-Whitney showed percentage differences in measures obtained with motion-corrupt conventional MPRAGE compared to DISORDER data were significantly greater than in those obtained using motion-free conventional MPRAGE data in 22/58 structures.
CONCLUSION
In the absence of motion, morphometric measures obtained using DISORDER are largely consistent with those from conventional MPRAGE data, whereas improved reliability is obtained by DISORDER for motion-degraded scans. This study validates the use of DISORDER for brain morphometric studies in children.
目的
本研究旨在验证一种用于小儿脑形态测量的回顾性运动校正技术，即利用编码冗余进行重建去模糊的分布式和非相干采样顺序（DISORDER）。
方法
在3T条件下，对37名7至8岁儿童采集了两个T1加权MPRAGE 3D数据集：一个采用传统线性相位编码，另一个采用DISORDER。MPRAGE图像被评为无运动或有运动干扰。使用FreeSurfer测量皮质形态和区域脑容量，使用FSL-FIRST测量皮质下灰质（GM），使用HippUnfold测量海马体。采用组内相关系数（ICC）来确定一致性。使用曼-惠特尼检验来测试使用DISORDER获得的测量值与（i）无运动干扰和（ii）有运动干扰的传统MPRAGE数据之间的差异。
结果
对于大多数皮质下GM（无运动干扰，0.75 - 0.96；有运动干扰，0.62 - 0.98）和区域脑容量（无运动干扰，0.47 - 0.99；有运动干扰，0.54 - 0.99），传统MPRAGE和DISORDER数据之间的ICC测量结果良好/优秀，但杏仁核和伏隔核除外（无运动干扰，0.38 - 0.65；有运动干扰，0.1 - 0.42）。对于有运动干扰的传统MPRAGE数据，海马体体积（无运动干扰，0.65 - 0.99；有运动干扰，0.11 - 0.91）和皮质测量值（无运动干扰，0.76 - 0.98；有运动干扰，0.09 - 0.74）的这些值不太一致。曼-惠特尼检验显示，与DISORDER数据相比，有运动干扰的传统MPRAGE获得的测量值的百分比差异在22/58个结构中显著大于无运动干扰的传统MPRAGE数据获得的测量值。
结论
在无运动的情况下，使用DISORDER获得的形态测量值在很大程度上与传统MPRAGE数据的测量值一致，而对于运动退化的扫描，DISORDER提高了可靠性。本研究验证了DISORDER在儿童脑形态测量研究中的应用。
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