间充质干细胞修饰的天然生物活性化合物：再生医学的新希望。

Natural bioactive compounds modified with mesenchymal stem cells: new hope for regenerative medicine.

作者信息

Wu Jingjing, Ge Ying, Huang Wendi, Zhang Li, Huang Juan, Huang Nanqu, Luo Yong

机构信息

Department of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.

Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.

出版信息

Front Bioeng Biotechnol. 2025 May 9;13:1446537. doi: 10.3389/fbioe.2025.1446537. eCollection 2025.

DOI:10.3389/fbioe.2025.1446537

PMID:40416310

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12098461/

Abstract

Mesenchymal stem cells (MSCs) have the potential to differentiate into various cell types, providing important sources of cells for the development of regenerative medicine. Although MSCs have various advantages, there are also various problems, such as the low survival rate of transplanted cells and poor migration and homing; therefore, determining how to reform MSCs to improve their utilization is particularly important. Although many natural bioactive compounds have shown great potential for improving MSCs, many mechanisms and pathways are involved; however, in the final analysis, natural bioactive compounds promoted MSC proliferation, migration and homing and promoted differentiation and antiaging. This article reviews the regulatory effects of natural bioactive compounds on MSCs to provide new ideas for the therapeutic effects of modified MSCs on diseases.

摘要

间充质干细胞（MSCs）具有分化为多种细胞类型的潜力，为再生医学的发展提供了重要的细胞来源。尽管MSCs有诸多优势，但也存在各种问题，如移植细胞存活率低、迁移和归巢能力差等；因此，确定如何改造MSCs以提高其利用率尤为重要。虽然许多天然生物活性化合物已显示出改善MSCs的巨大潜力，但涉及许多机制和途径；然而，归根结底，天然生物活性化合物促进了MSCs的增殖、迁移和归巢，并促进了分化和抗衰老。本文综述了天然生物活性化合物对MSCs的调节作用，为改造后的MSCs对疾病的治疗效果提供新思路。