Efficacy and Safety of Nitrous Oxide (NO) Inhalation Sedation Compared to Other Sedative Agents in Dental Procedures: A Systematic Review with Meta-Analysis.

: Dental procedures can be distressing, particularly for patients who are anxious or uncooperative. In such cases, effective sedation not only facilitates the clinician's work but also enhances patient comfort and acceptance of dental care. Nitrous oxide (NO) has been widely employed as a sedative agent in dental practice. This systematic review aimed to assess the efficacy and safety of NO compared to alternative sedative agents and techniques in dental surgical procedures. This review protocol was prospectively registered on PROSPERO (CRD42020213429) and conducted in accordance with PRISMA guidelines. A total of 1809 records were screened (1134 from Embase, 638 from PubMed, and 37 from CENTRAL). The meta-analysis focused on the following three primary outcomes: 1. Patient satisfaction: Eight studies comprising 422 participants (165 treated with NO and 176 with other sedatives) were included. 2. Recall of the procedure: Five studies with a total of 288 patients (68 receiving NO and 64 other agents) assessed patients' ability to recall tooth extraction. 3. Successful completion of the procedure: Three studies involving 1578 patients (434 treated with NO and 989 with alternative sedation methods) were analyzed. No statistically significant differences were observed between NO and other sedative techniques across all outcomes evaluated. Safety could not be adequately assessed as none of the included studies systematically investigated this outcome. Further high-quality research is warranted to rigorously evaluate the safety profiles of various sedation strategies in dental surgery.