Yin Yifan, Ye Liang, Chen Min, Liu Hao, Miao Jingkun
Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing 401120, China.
Department of Pediatrics, Women and Children's Hospital of Chongqing Medical University, Chongqing 401120, China.
Vaccines (Basel). 2025 Apr 30;13(5):490. doi: 10.3390/vaccines13050490.
: Concerns about the occurrence of autoimmune diseases are one of the main reasons influencing the uptake of the human papillomavirus (HPV) vaccine. Limited evidence exists regarding the relationship between HPV vaccination and the risk of Hashimoto's thyroiditis (HT). Therefore, the purpose of this study was to examine the association between HPV vaccination and the risk of HT development in American women. : Using the National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2012, we conducted a cross-sectional study of 2717 women aged 18-59 with comprehensive data on relevant HPV vaccination status, HPV DNA vaginal swab results, and thyroid function. The relationship between HPV vaccination and the risk of HT development was explored by weighted logistic regression, while the association between HPV vaccination and thyroid peroxidase antibodies (TPOAb)/thyroglobulin antibodies (TGAb) levels was analyzed by weighted linear regression. : In the fully adjusted model, HPV vaccination was associated with an 87% decrease in the risk of developing HT (OR 0.13; 95% CI 0.02, 0.76). Furthermore, weighted linear regression demonstrated significant negative associations between HPV vaccination and TPOAb levels (-22.27 (-34.86, -9.68), = 0.001) and TGAb levels (-7.53 (-14.88, -0.18), = 0.045). HPV vaccination was significantly negatively correlated with the risk of HT development and TPOAb/TGAb levels. : We advocate for adherence to vaccination guidelines, which could confer dual protective benefits against HPV and potentially reduce the risk of HT development.
对自身免疫性疾病发生的担忧是影响人乳头瘤病毒（HPV）疫苗接种率的主要原因之一。关于HPV疫苗接种与桥本甲状腺炎（HT）风险之间的关系，现有证据有限。因此，本研究的目的是探讨美国女性中HPV疫苗接种与HT发生风险之间的关联。
利用2007年至2012年的美国国家健康与营养检查调查（NHANES）数据，我们对2717名年龄在18 - 59岁之间的女性进行了一项横断面研究，这些女性具有关于相关HPV疫苗接种状况、HPV DNA阴道拭子结果和甲状腺功能的全面数据。通过加权逻辑回归探讨HPV疫苗接种与HT发生风险之间的关系，同时通过加权线性回归分析HPV疫苗接种与甲状腺过氧化物酶抗体（TPOAb）/甲状腺球蛋白抗体（TGAb）水平之间的关联。
在完全调整模型中，HPV疫苗接种与HT发生风险降低87%相关（比值比0.13；95%置信区间0.02，0.76）。此外，加权线性回归显示HPV疫苗接种与TPOAb水平（-22.27（-34.86，-9.68），P = 0.001）和TGAb水平（-7.53（-14.88，-0.18），P = 0.045）之间存在显著的负相关。HPV疫苗接种与HT发生风险以及TPOAb/TGAb水平显著负相关。
我们主张遵守疫苗接种指南，这可能对HPV具有双重保护益处，并有可能降低HT发生的风险。
