如果含过氧化苯甲酰的产品退出市场对痤疮治疗方案的影响。

The Impact on Acne Treatment Regimens if Benzoyl Peroxide-Containing Products are Removed From the Market.

作者信息

Dhawan Sunil, Nardo Christopher J

出版信息

J Drugs Dermatol. 2025 Jun 1;24(6):586-589. doi: 10.36849/JDD.8840.

Abstract

Benzyl peroxide (BPO) has been an important component of many acne treatment regimens. However, an independent testing laboratory, Valisure, filed a Citizen’s Petition with the US Food and Drug Administration (FDA) requesting the removal of BPO products from the market. Their testing demonstrated that when exposed to elevated temperatures which could occur during shipping, marketed BPO products can form over 800 times the FDA concentration limits of benzene, a class 1 carcinogen. In this review, we aim to describe what a post-BPO removal acne treatment regimen might look like based on currently approved products and products in late-stage development. Citation: Dhawan S, Nardo CJ. The impact on acne treatment regimens if benzoyl peroxide-containing products are removed from the market. J Drugs Dermatol. 2025;24(6):586-589. doi:10.36849/JDD.8840R1.

摘要

过氧化苯甲酰（BPO）一直是许多痤疮治疗方案的重要组成部分。然而，一家独立检测实验室Valisure向美国食品药品监督管理局（FDA）提交了一份公民请愿书，要求将含BPO的产品退市。他们的检测表明，在运输过程中可能出现的高温条件下，市售的BPO产品所形成的苯含量可超过FDA规定浓度限值的800倍，而苯是一种1类致癌物。在本综述中，我们旨在根据目前已获批的产品以及处于后期研发阶段的产品，描述去除BPO后痤疮治疗方案可能是什么样的。引文：Dhawan S, Nardo CJ.含过氧化苯甲酰产品退市对痤疮治疗方案的影响。《药物皮肤病学杂志》。2025；24(6):586 - 589。doi:10.36849/JDD.8840R1 。