NLRP3炎性小体在坏死性小肠结肠炎中的作用。
The role of NLRP3 inflammasome in necrotizing enterocolitis.
作者信息
Chen Xiuhui, Long Rui, Xu Fengdan, Ye Weijun, Li Ning
机构信息
Dongguan Children's Hospital Affiliated to Guangdong Medical University, The Eighth People's Hospital of Dongguan, Dongguan, 523000, China.
Key Laboratory of Precision Pharmacy and Pharmaceutical Basic Research, Department of Pharmacy & The Eighth People's Hospital of Dongguan, Dongguan, 523000, China.
出版信息
Pediatr Res. 2025 Jun 5. doi: 10.1038/s41390-025-04081-2.
This review explores the association between the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasomes and necrotizing enterocolitis (NEC) in neonates. It underscores the role of NLRP3 inflammasome overactivation in NEC pathogenesis and proposes that inhibiting NLRP3 inflammasome activation may improve therapeutic benefits. This review examines various strategies to inhibit NLRP3 inflammasome activation, detailing their pharmacological mechanisms. IMPACT: The aim of this review is to discuss the role of NLRP3 inflammasome in the progression of NEC. Abnormal NLRP3 inflammasome activation in patients with NEC and experimental models. Molecules and proteins have been identified as regulators of NLRP3 inflammasome activity, offering avenues for NEC treatment. The NLRP3 inflammasome is a key contributor to NEC. Novel NLRP3 inflammasome inhibitors are the focus of the development of NEC therapeutics.
本综述探讨了含NOD样受体吡啉结构域蛋白3（NLRP3）炎性小体与新生儿坏死性小肠结肠炎（NEC）之间的关联。强调了NLRP3炎性小体过度激活在NEC发病机制中的作用，并提出抑制NLRP3炎性小体激活可能改善治疗效果。本综述研究了抑制NLRP3炎性小体激活的各种策略，并详细阐述了其药理机制。影响：本综述的目的是讨论NLRP3炎性小体在NEC进展中的作用。NEC患者和实验模型中NLRP3炎性小体的异常激活。已鉴定出分子和蛋白质作为NLRP3炎性小体活性的调节因子，为NEC治疗提供了途径。NLRP3炎性小体是NEC的关键促成因素。新型NLRP3炎性小体抑制剂是NEC治疗药物开发的重点。
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