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[小儿群体中的吉兰-巴雷综合征。是活动性感染还是长期新冠的后果?]

[Guillain Barré syndrome in the paediatric population. Consequence of active infection or long Covid?].

作者信息

Barroso Erika, Tuta-Quintero Eduardo, Olivella Juan, Aragón Camila, Vásquez Lorena, Acosta Lina, Pinzón Oscar, Pantoja Carlos A, Collazos Estefanía, Ascanio Yesica P, Morales Violett Del Carmen Del Río, Kuan Juan C, Velásquez Liley A, Díaz Yeimy N, Pimentel Juan

机构信息

Facultad de Medicina, Universidad de La Sabana, Chía, Colombia.

Facultad de Medicina, Universidad de Militar Nueva Granada, Bogotá, Colombia.

出版信息

Rev Colomb Reumatol. 2022 Oct-Dec;29(4):335-346. doi: 10.1016/j.rcreu.2022.05.003. Epub 2022 Aug 10.

Abstract

BACKGROUND

Guillain-Barré syndrome is a polyradiculoneuropathy that has been associated with infectious diseases as triggers. There is currently little medical evidence exploring the relationship between the development of Guillain-Barré syndrome caused by SARS-CoV-2 infection and long Covid.

OBJECTIVE

To synthesize the medical evidence that describes the relationship between post Covid syndrome and Guillain-Barré syndrome in the paediatric population.

METHODOLOGY

A scoping review was developed using Scopus and PubMed databases, including analytical and/or descriptive experimental and observational studies.

RESULTS

The main clinical manifestations presented by paediatric patients were distal and ascending weakness in the lower limbs and myalgia. The diagnostic approach was based on clinical findings, imaging findings on spinal magnetic resonance and electromyography. The therapeutic strategy is based on the use of intravenous human immunoglobulins.

CONCLUSION

Guillain-Barré syndrome is a frequent disease in the paediatric population with active SARS-CoV-2 infection or in survivors, however, it is necessary to encourage further clinical studies that increase the medical literature that describes this association.

摘要

背景

吉兰 - 巴雷综合征是一种多神经根神经病,与感染性疾病作为触发因素有关。目前几乎没有医学证据探索由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染引起的吉兰 - 巴雷综合征的发展与长期新冠之间的关系。

目的

综合描述儿科人群中新冠后综合征与吉兰 - 巴雷综合征之间关系的医学证据。

方法

使用Scopus和PubMed数据库进行范围综述,包括分析性和/或描述性实验性和观察性研究。

结果

儿科患者呈现的主要临床表现为下肢远端及上行性无力和肌痛。诊断方法基于临床发现、脊柱磁共振成像结果和肌电图。治疗策略基于使用静脉注射人免疫球蛋白。

结论

吉兰 - 巴雷综合征在患有活动性SARS-CoV-2感染的儿科人群或幸存者中是一种常见疾病,然而,有必要鼓励进一步的临床研究,以增加描述这种关联的医学文献。

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本文引用的文献

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Guillain-Barré Syndrome with Normal Nerve Conduction Study Associated with COVID-19 Infection in a Child.
Indian J Pediatr. 2022 Jun;89(6):631. doi: 10.1007/s12098-022-04097-0. Epub 2022 Feb 15.
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Multisystem inflammatory syndrome and COVID-19: a scoping review.
Bol Med Hosp Infant Mex. 2022 Mar 3;79(2):69-82. doi: 10.24875/BMHIM.21000073.
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The Youngest Pediatric Guillain Barre Syndrome associated with COVID-19 Infection.
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