血脂异常与胃癌之间的关联：从发病机制到预防及治疗策略
Correlation between dyslipidaemia and gastric cancer: pathogenesis to prevention and treatment strategies.
作者信息
Wu Tao, Zhang Lingna, Tian Jiao, Lu Yuyuan, Yang Yan, Yang Xin, Jin Penghui, Gu Yuanhui, Wang Xiaoke, Yi Lin
机构信息
School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China.
Department of General Surgery, Gansu Provincial Hospital, Lanzhou, 730000, Gansu Province, China.
出版信息
Lipids Health Dis. 2025 Jun 7;24(1):204. doi: 10.1186/s12944-025-02625-3.
As the sixth most common cancer in the world, the development of gastric cancer (GC) is influenced by many factors. Recent studies have revealed a strong association between dyslipidaemia and GC. In this paper, the relationships between dyslipidaemia and GC are discussed in depth. We review the development of GC through the mechanisms of the inflammatory response, signalling pathways, and apolipoprotein function, and the intersecting targets of atherosclerosis and GC are explored. The synergistic effects of Helicobacter pylori infection and dyslipidaemia on the development of GC are also analysed, and the potential value of statins in the prevention and treatment of GC is discussed. In this review, we systematically investigated the relationship between dyslipidaemia and GC to provide new ideas for GC prevention and treatment.
作为全球第六大常见癌症，胃癌（GC）的发生受多种因素影响。近期研究揭示了血脂异常与胃癌之间存在密切关联。本文深入探讨了血脂异常与胃癌之间的关系。我们通过炎症反应机制、信号通路和载脂蛋白功能来回顾胃癌的发展过程，并探索动脉粥样硬化与胃癌的交叉靶点。还分析了幽门螺杆菌感染和血脂异常对胃癌发生的协同作用，并讨论了他汀类药物在胃癌预防和治疗中的潜在价值。在本综述中，我们系统地研究了血脂异常与胃癌之间的关系，为胃癌的预防和治疗提供新思路。
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