维生素D在从急性疼痛向慢性疼痛转变过程中的作用：一项系统综述。

Vitamin D in the Transition from Acute to Chronic Pain: A Systematic Review.

作者信息

Abrego-Guandique Diana Marisol, Ilari Sara, Nucera Saverio, Passacatini Lucia Carmela, Cione Erika, Cannataro Roberto, Gallelli Luca, Caroleo Maria Cristina, Mollace Vincenzo, Muscoli Carolina

机构信息

Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.

Department for the Promotion of Human Sciences and Quality of Life, San Raffaele Roma University, 00166 Rome, Italy.

出版信息

Nutrients. 2025 Jun 1;17(11):1912. doi: 10.3390/nu17111912.

DOI:10.3390/nu17111912

PMID:40507180

Abstract

BACKGROUND

The transition from acute to chronic pain is an important clinical phenomenon that significantly impacts the healthcare system. Despite decades of research, preventing this transition remains a complex challenge. Many studies have explored the various factors that contribute to the development of chronic pain, but the underlying mechanisms are still largely unclear. In this frame, vitamin D (VD) plays an important role in pain mechanism development, with emerging evidence suggesting it influences pain perception, inflammation, and nerve function.

METHODS

A total of 14 eligible original research articles were identified.

RESULTS

Our qualitative analysis showed that VD did not directly influence the transition from acute to chronic pain, but it affected pain intensity, improving outcomes in patients at risk of developing chronic pain.

CONCLUSIONS

Additional randomized clinical trials, particularly double-blind, placebo-controlled studies, which are regarded as the gold standard in clinical research, are warranted to evaluate the role of vitamin D in the progression from acute to chronic pain.

摘要

背景

从急性疼痛向慢性疼痛的转变是一种重要的临床现象，对医疗保健系统有重大影响。尽管经过数十年研究，但预防这种转变仍然是一项复杂的挑战。许多研究探讨了导致慢性疼痛发展的各种因素，但其潜在机制仍大多不明。在此背景下，维生素D（VD）在疼痛机制发展中起重要作用，新出现的证据表明它会影响疼痛感知、炎症和神经功能。