铜介导的放射化学：历史影响、当前趋势及未来可能性。

Copper-mediated radiochemistry: historical impact, current trends, and future possibilities.

作者信息

Bowden Gregory D, Müller Marius, Herth Matthias M, Sanford Melanie S, Scott Peter J H

机构信息

Department of Radiology, University of Michigan, 1301 Catherine, Ann Arbor, MI 48109 USA.

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany.

出版信息

Npj Imaging. 2025 Jun 10;3:25. doi: 10.1038/s44303-025-00087-x. eCollection 2025.

DOI:10.1038/s44303-025-00087-x

PMID:40510251

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12151854/

Abstract

Modern approaches to copper-mediated radiolabeling have proven an important addition to the radiochemical toolbox. Radiopharmaceuticals prepared using this methodology have been translated from preclinical PET studies into clinical trials, and it has been adapted for radionuclides beyond fluorine-18, enabling theranostic applications. The methodology is also beginning to benefit from AI-assisted radiochemistry development. This perspective discusses the history, state-of-the-art, and potential future impact of copper-mediated radiochemistry on radiopharmaceutical development.

摘要

事实证明，现代铜介导的放射性标记方法是放射化学工具箱的一项重要补充。使用这种方法制备的放射性药物已从临床前PET研究转化为临床试验，并且该方法已适用于除氟-18之外的放射性核素，从而实现了诊疗应用。该方法也开始受益于人工智能辅助的放射化学发展。本文综述了铜介导的放射化学在放射性药物研发方面的历史、现状以及对未来可能产生的影响。