Jadhav Deepali, Ambad Ranjit S
Department of Physiology, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research, Sawangi (M), Wardha, Maharashtra, India.
Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (M), Wardha, Maharashtra, India.
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S179-S180. doi: 10.4103/jpbs.jpbs_46_25. Epub 2025 Apr 12.
Cellular profiling and human neurophysiology are significant points of convergence between molecular, biological, and neural science. Cellular phenotyping refers to the breaking down of cells to understand their molecular and functional characteristics. Human neurophysiology, in contrast, is re-concerned with function and centers on the human neural system. This work offers a systematic view of these domains and intends to disentangle how these domains interact in understanding neural processes, cell responses, and diseases. This research uses modern approaches, including single-cell RNA sequencing and electrophysiological approaches, to explore cell heterogeneity and neurophysiological phenotypes in human specimens. The overlying cross-sectional approach allows for the accurate determination of cell subtypes and their involvement in specific neurophysiological functions, thus facilitating the design of highly specific treatment plans.
细胞分析和人类神经生理学是分子科学、生物学和神经科学之间重要的交汇点。细胞表型分析是指对细胞进行分解以了解其分子和功能特征。相比之下,人类神经生理学重新关注功能,并以人类神经系统为核心。这项工作提供了对这些领域的系统观点,并旨在理清这些领域在理解神经过程、细胞反应和疾病方面是如何相互作用的。本研究采用现代方法,包括单细胞RNA测序和电生理方法,来探索人类样本中的细胞异质性和神经生理表型。这种总体的横断面方法能够准确确定细胞亚型及其在特定神经生理功能中的作用,从而有助于设计高度特异性的治疗方案。