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糖尿病患者中非酒精性脂肪性肝病的发生情况:一项对比研究。

The Occurrence of Non-Alcoholic Fatty Liver Disease among Individuals with Diabetes Mellitus: A Comparative Study.

作者信息

Shah Ashay, Bakerywala Arifa, Brahmbhatt Riya N, Shaikh Heena, Bhutak Nidhi Shashikant, Singh Renu

机构信息

Clinical Research Professional, Department of Doctorate, University of the Cumberlands, Kentucky, USA.

Department of Pediatric Dentistry, Tufts University School of Dental Medicine, Boston, MA, United States.

出版信息

J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S767-S769. doi: 10.4103/jpbs.jpbs_2016_24. Epub 2025 Feb 28.

Abstract

AIM

This research aimed to investigate the occurrence and trends of non-alcoholic fatty liver disease (NAFLD) in individuals diagnosed with type 2 diabetes mellitus.

MATERIAL AND METHODS

During the course of the study, a total of 100 patients with a diagnosis of type 2 diabetes mellitus were enrolled by researchers, adhering to defined inclusion and exclusion criteria. The diagnosis of NAFLD was confirmed via ultrasonography, which revealed a bright liver appearance.

RESULTS

The ultrasonography analysis revealed that 50% of the patients were diagnosed with fatty liver, leading to their classification in group A. The remaining patients, who exhibited no signs of fatty liver, were assigned to Group B. Group A exhibited significantly higher levels of serum AST, serum ALT, and serum alkaline phosphatase in comparison to Group B. Group B showed an elevated Serum AST/ALT ratio when compared to group A.

CONCLUSION

The rising rates of obesity are increasingly linked to a surge in conditions such as type 2 diabetes mellitus and non-alcoholic fatty liver disease, has rendered the management of these patients more complex than ever. Clinicians must recognize the extrahepatic manifestations associated with NAFLD, as early identification of T2DM is crucial for effectively managing these patients.

摘要

目的

本研究旨在调查2型糖尿病患者中非酒精性脂肪性肝病(NAFLD)的发生情况及趋势。

材料与方法

在研究过程中,研究人员按照既定的纳入和排除标准,共招募了100例诊断为2型糖尿病的患者。通过超声检查确认NAFLD的诊断,超声显示肝脏外观明亮。

结果

超声检查分析显示,50%的患者被诊断为脂肪肝,归入A组。其余无脂肪肝迹象的患者被分配到B组。与B组相比,A组的血清谷草转氨酶(AST)、血清谷丙转氨酶(ALT)和血清碱性磷酸酶水平显著更高。与A组相比,B组的血清AST/ALT比值升高。

结论

肥胖率的上升与2型糖尿病和非酒精性脂肪性肝病等疾病的激增越来越相关,这使得这些患者的管理比以往任何时候都更加复杂。临床医生必须认识到与NAFLD相关的肝外表现,因为早期识别2型糖尿病对于有效管理这些患者至关重要。

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