Dalwadi Shrey, Abidi Zehara, Singh Avneet, Garcia Alexander, Shivaprasad Punitha, Dalal Kunal
Cooper Medical School of Rowan University, Camden, NJ, USA.
Touro College of Osteopathic Medicine, Harlem, NY, USA.
SAGE Open Med Case Rep. 2025 Jun 13;13:2050313X251347424. doi: 10.1177/2050313X251347424. eCollection 2025.
Pancreatic neuroendocrine tumors are an uncommon group of insidious neoplasms that are often diagnosed in the advanced stages. Diagnosing pancreatic neuroendocrine tumors involves proper biopsy technique and immunohistochemistry, while treatments include targeted therapies and systemic chemotherapy. When diagnosed early, patients with localized disease generally have a positive prognosis. We share a case of a 56-year-old man presenting to the emergency department with acute abdominal pain found to have poorly differentiated pancreatic neuroendocrine tumor with metastasis on repeat endoscopic ultrasound-guided fine needle biopsy. Despite multiple treatment changes, sustained tumor presence led to numerous complications and ultimately patient death. This case highlights the nuances and challenges of diagnosing and treating a rare pancreatic neuroendocrine tumor, such as the importance of biopsy technique.
胰腺神经内分泌肿瘤是一组罕见的隐匿性肿瘤，常在晚期才被诊断出来。诊断胰腺神经内分泌肿瘤需要恰当的活检技术和免疫组化，而治疗方法包括靶向治疗和全身化疗。早期诊断时，局限性疾病患者的预后通常较好。我们分享一例56岁男性患者的病例，该患者因急性腹痛到急诊科就诊，经重复内镜超声引导下细针穿刺活检发现患有低分化胰腺神经内分泌肿瘤并伴有转移。尽管多次更改治疗方案，但肿瘤持续存在导致了诸多并发症，最终患者死亡。该病例凸显了诊断和治疗罕见胰腺神经内分泌肿瘤的细微差别和挑战，比如活检技术的重要性。
