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瑞典斯德哥尔摩SARS-CoV-2感染个体中COVID-19后门诊就诊的决定因素:一项基于人群的队列研究

Determinants of post COVID-19 clinic attendance among SARS-CoV-2-infected individuals in Stockholm, Sweden: a population-based cohort study.

作者信息

Hedberg Pontus, Af Geijerstam Peder, Karlsson Valik John, Almgren-Lidman Christer, Ternhag Anders, Naucler Pontus

机构信息

Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

Primary Health Care Center Cityhälsan Centrum, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

出版信息

BMJ Open. 2025 Jun 17;15(6):e098344. doi: 10.1136/bmjopen-2024-098344.

Abstract

OBJECTIVES

Investigate determinants of post-COVID-19 condition (PCC) clinic attendance among participants not hospitalised versus hospitalised during the SARS-CoV-2 infection.

DESIGN

Retrospective cohort study.

SETTING

Six population-based registers with high coverage to cover all adults residing in Stockholm County, Sweden.

PARTICIPANTS

Adults residing in Stockholm County on 31 January 2020, with a SARS-CoV-2 infection through 30 November 2022, who did not die or move out of Stockholm County within 90 days.

PRIMARY OUTCOME MEASURES

PCC clinic attendance from 90 days after the SARS-CoV-2 test until date of death, date of moving out, or 30 November 30,2023.

RESULTS

Of non-hospitalised and hospitalised participants, 737 of 464 674 (0.2%) and 433 of 23 374 (1.9%), respectively, attended a PCC clinic. A total of 75 878 (16.3%) of non-hospitalised participants and 6190 (26.5%) of hospitalised participants presented with new-onset symptoms that could indicate PCC in primary care. The strongest determinants of attendance among non-hospitalised participants were mental health disorder (adjusted risk ratio (aRR) 2.57, 95% CI 2.21 to 2.98), asthma (2.39, 1.97-2.92) and >4 PCC symptoms in 2019 (2.27, 1.60-3.24), and among hospitalised participants were >31 sick days in 2019 (1.94, 1.47-2.56), 1-30 sick days in 2019 (1.56, 1.06-2.29) and obesity (1.51, 1.19-1.93). The most common clinical presentation was fatigue (n=526, 71.4%) among non-hospitalised and dyspnoea (n=148, 34.2%) among hospitalised participants.

CONCLUSIONS

PCC clinic attendance characteristics differed between non-hospitalised and hospitalised participants. Distinguishing PCC from conditions with overlapping symptoms and determining the appropriate level of care may be challenging, with risk of resource displacement effects and inappropriate care.

摘要

目的

调查在感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)期间未住院与住院的参与者中,新冠后状况(PCC)门诊就诊的决定因素。

设计

回顾性队列研究。

设置

六个高覆盖率的基于人群的登记处,以涵盖居住在瑞典斯德哥尔摩县的所有成年人。

参与者

2020年1月31日居住在斯德哥尔摩县、在2022年11月30日前感染SARS-CoV-2、在90天内未死亡或搬出斯德哥尔摩县的成年人。

主要结局指标

从SARS-CoV-2检测后90天到死亡日期、迁出日期或2023年11月30日的PCC门诊就诊情况。

结果

在未住院和住院的参与者中,分别有464674人中的737人(0.2%)和23374人中的433人(1.9%)前往PCC门诊就诊。共有75878名(16.3%)未住院参与者和6190名(26.5%)住院参与者在初级保健中出现了可能提示PCC的新发症状。未住院参与者中就诊的最强决定因素是精神健康障碍(调整风险比(aRR)2.57,95%置信区间2.21至2.98)、哮喘(2.39,1.97 - 2.92)以及2019年有超过4种PCC症状(2.27,1.60 - 3.24);住院参与者中的决定因素是2019年病假超过31天(1.94,1.47 - 2.56)、2019年病假1 - 30天(1.56,1.06 - 2.29)和肥胖(1.51,1.19 - 1.93)。最常见的临床表现是未住院参与者中的疲劳(n = 526,71.4%)和住院参与者中的呼吸困难(n = 148,34.2%)。

结论

未住院和住院参与者的PCC门诊就诊特征有所不同。将PCC与症状重叠的疾病区分开来并确定适当的护理水平可能具有挑战性,存在资源替代效应和不适当护理的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bfa/12182103/d66b9227041d/bmjopen-15-6-g001.jpg

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