Klopack Eric T, Hernandez Belinda, Potter Claire, Faul Jessica D, Hill Claire, Smyth Laura, Mitchell Colter, McCrory Cathal, Kenny Rose Anne, McKnight Amy Jayne, McGuinness Bernadette, Crimmins Eileen M
University of Southern California, Leonard Davis School of Gerontology, United States.
The Irish Longitudinal Study on Ageing, Dept. of Medical Gerontology, School of Medicine, Trinity College Dublin, Ireland.
Soc Sci Med. 2025 Sep;381:118287. doi: 10.1016/j.socscimed.2025.118287. Epub 2025 May 30.
Research utilizing epigenetic clocks has accelerated in recent years, but it is largely unknown how consistently these measures perform across country and cultural contexts, and thus, how useful they are for understanding the large differences in health outcomes across countries. We assess epigenetic aging in three countries (the US, Ireland, and Northern Ireland) utilizing survey data from each country and evaluated how these measures are associated with three well-studied health behaviors (heavy alcohol use, smoking, and BMI). In general, we found remarkable consistency across these studies, suggesting epigenetic clocks are potentially highly useful for monitoring health and aging processes in different contexts. More research is needed on other health risks and in non-Western and low- and middle-income countries.
近年来，利用表观遗传时钟的研究加速发展，但在不同国家和文化背景下这些测量方法的一致性如何，以及它们对于理解各国健康结果的巨大差异有多大用处，在很大程度上尚不清楚。我们利用来自美国、爱尔兰和北爱尔兰这三个国家的调查数据评估表观遗传衰老情况，并评估这些测量方法与三种经过充分研究的健康行为（大量饮酒、吸烟和体重指数）之间的关联。总体而言，我们在这些研究中发现了显著的一致性，这表明表观遗传时钟对于监测不同背景下的健康和衰老过程可能非常有用。在其他健康风险以及非西方和低收入及中等收入国家还需要开展更多研究。
