共刺激连接：CARMIL2和CD28。
Costimulatory connections: CARMIL2 and CD28.
作者信息
Kane Lawrence P
机构信息
Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
J Exp Med. 2025 Aug 4;222(8). doi: 10.1084/jem.20250896. Epub 2025 Jun 20.
Abstract
In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20250339) report that a gain-of-function mutation in CARMIL2, previously identified in patients, is sufficient to replace the contribution of CD28 to NF-κB activation and downstream effects in T cells, including in the setting of an anti-tumor response.
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