甘油三酯-葡萄糖指数与颅内动脉瘤破裂之间的关联：一项回顾性研究的结果
Association between triglyceride-glucose index and intracranial aneurysm rupture: findings from a retrospective study.
作者信息
Lin Jiancheng, Feng Xin, Wen Zhuohua, Huang Chi, Huang Mengshi, Huang Jiwan, Ge Runze, Xu Anqi, Ma Gengwu, Shi Hongyu, Hu Yuqi, Yuan Hao, Li Can, Yi Ruizhe, Jin Yuheng, Liang Shuyin, Zhang Xin, Li Xifeng, Duan Chuanzhi
机构信息
Neurosurgery Center, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
出版信息
Neurosurg Rev. 2025 Jun 21;48(1):521. doi: 10.1007/s10143-025-03680-1.
BACKGROUND
Limited studies investigated the relationship between triglyceride-glucose (TyG) index and the rupture of intracranial aneurysm (IA). We aimed to examine the association between TyG index and IA rupture in patients diagnosed with IAs.
MATERIALS AND METHODS
Participants with IAs from January 2012 to April 2022 were retrospectively included. The association between TyG index and IA rupture was assessed by multivariable-adjusted logistic regression models, restricted cubic spline (RCS) models and subgroup analysis.
RESULTS
Among 1535 patients with 1901 IAs, 596 (31.4%) IA rupture cases occurred. The incidence of IA rupture rose along with elevated TyG index. The positive correlation persisted after adjusting for age, sex, and other covariates, with adjusted odds ratios of 1.64 (95% CI 1.26-2.14) and 1.85 (95% CI 1.41-2.42) for TyG index tertiles 2 and 3. RCS curves showed a linear trend of TyG index with the risk of IA rupture. In the subgroup analysis, similar relationships were observed across subgroups defined by age, sex, hypertension, TC and aneurysm size.
CONCLUSIONS
There is a significant association between TyG index and the occurrence of IA rupture, indicating TyG index has the potential for risk assessment of IA rupture. Further prospective studies are warranted to validate its clinical utility.
TRIAL REGISTRATION
ClinicalTrials.gov (NCT06456814). Registered on June 7, 2024.
背景
关于甘油三酯-葡萄糖（TyG）指数与颅内动脉瘤（IA）破裂之间关系的研究有限。我们旨在研究确诊为IA的患者中TyG指数与IA破裂之间的关联。
材料与方法
回顾性纳入2012年1月至2022年4月期间患有IA的参与者。通过多变量调整逻辑回归模型、受限立方样条（RCS）模型和亚组分析评估TyG指数与IA破裂之间的关联。
结果
在1535例患有1901个IA的患者中，发生了596例（31.4%）IA破裂病例。IA破裂的发生率随着TyG指数的升高而上升。在调整年龄、性别和其他协变量后，这种正相关仍然存在，TyG指数第二和第三三分位数的调整优势比分别为1.64（95%CI 1.26 - 2.14）和1.85（95%CI 1.41 - 2.42）。RCS曲线显示TyG指数与IA破裂风险呈线性趋势。在亚组分析中，在按年龄、性别、高血压、总胆固醇和动脉瘤大小定义的亚组中观察到了类似的关系。
结论
TyG指数与IA破裂的发生之间存在显著关联，表明TyG指数具有IA破裂风险评估的潜力。需要进一步的前瞻性研究来验证其临床实用性。
试验注册
ClinicalTrials.gov（NCT06456814）。于2024年6月7日注册。
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