血管生成素：关节相关疾病发病机制中的多面介质

Angiopoietins: multifaceted mediators in the pathogenesis of joint-related disorders.

作者信息

Song Ruifeng, Cheng Zhebing, Wu Zuping, Guan Guzhe, Liu Hengyuan, Feng Xiaoxia, Chen Qian

机构信息

Stomatology Hospital, School of Stomatology, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, 310000, China.

Affiliated Hospital of Stomatology, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310016, China.

出版信息

Histochem Cell Biol. 2025 Jun 20;163(1):68. doi: 10.1007/s00418-025-02395-0.

DOI:10.1007/s00418-025-02395-0

PMID:40542206

Abstract

Joint-related diseases often involve multiple aspects of angiogenesis, alterations in the extracellular matrix (ECM), and inflammatory responses, causing pain and mobility problems for patients. Angiopoietins (Angs) are a protein family of secreted growth factors that have a variety of functions, including regulating angiogenesis, stabilizing blood vessels, and mediating changes in the ECM. The first Ang was discovered by Davis in COS cells, and since then, three more members of this protein family have been discovered. Among these four members, Ang-1 and Ang-2 play the most essential roles in joint diseases and are closely related to each other as ligands for the Tie-2 receptor. Ang-1 acts as an agonist at the Tie-2 receptor, while Ang-2 can act as either an agonist or antagonist of Tie-2 under specific conditions. This review describes the structure and general physiological functions of Angs and summarizes the role of Angs in joint-related diseases. It concludes with possible Ang-based therapeutic strategies.

摘要

关节相关疾病通常涉及血管生成、细胞外基质（ECM）改变和炎症反应等多个方面，给患者带来疼痛和行动不便问题。血管生成素（Angs）是一类分泌性生长因子的蛋白质家族，具有多种功能，包括调节血管生成、稳定血管以及介导ECM的变化。首个血管生成素由戴维斯在COS细胞中发现，此后又发现了该蛋白质家族的另外三个成员。在这四个成员中，血管生成素-1（Ang-1）和血管生成素-2（Ang-2）在关节疾病中发挥着最为关键的作用，并且作为Tie-2受体的配体，它们彼此密切相关。Ang-1作为Tie-2受体的激动剂，而在特定条件下，Ang-2既可以作为Tie-2的激动剂，也可以作为拮抗剂。本综述描述了血管生成素的结构和一般生理功能，并总结了血管生成素在关节相关疾病中的作用。最后阐述了基于血管生成素的可能治疗策略。