中药及其活性成分对瞬时受体电位锚蛋白1的调控
Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients.
作者信息
Fang Yunlong, Lei Chunxin, Wang Zihan, Liu Longxiao, Chen Yanyu, Chen Feng, Li Jingxuan, Tu Zhikun, Tao Qingwen, Xu Yuan
机构信息
National Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
出版信息
Front Pharmacol. 2025 Jun 6;16:1604765. doi: 10.3389/fphar.2025.1604765. eCollection 2025.
Transient receptor potential ankyrin 1 (TRPA1) has attracted substantial attention for its role as a thermal receptor and regulator of temperature and pain sensing. Notably, Traditional Chinese Medicine (TCM) has demonstrated pharmacological effects through regulation of TRPA1. In this review, we summarize the regulatory effects of TCM drugs and their active ingredients on TRPA1. A total of 31 TCM drugs were identified and categorized into three groups based on their function. Despite the progress in understanding the regulatory effects of TCM drugs and their constituents on TRPA1, further studies are needed to elucidate the molecular mechanisms involved. This review provides a molecular basis for the pharmacological effects of TCM drugs on TRPA1 regulation and offers evidence to support future research in this area.
瞬时受体电位锚蛋白1（TRPA1）作为一种热感受器以及温度和疼痛感知的调节器，已引起了广泛关注。值得注意的是，传统中药（TCM）已通过对TRPA1的调节显示出药理作用。在本综述中，我们总结了中药及其活性成分对TRPA1的调节作用。共鉴定出31种中药，并根据其功能分为三组。尽管在理解中药及其成分对TRPA1的调节作用方面取得了进展，但仍需要进一步研究以阐明其中涉及的分子机制。本综述为中药对TRPA1调节的药理作用提供了分子基础，并为该领域的未来研究提供了支持证据。
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