Shen Bingyi, Liu Haibin, Zhang Shuying, Chen Lihong, Yang Guangrui
School of Bioengineering, Dalian University of Technology, Dalian 116024, China.
School of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Biology (Basel). 2025 Jun 17;14(6):713. doi: 10.3390/biology14060713.
Aerobic exercise (AE) modulates vascular function through hemodynamic responses, thereby influencing cardiovascular health and risk, with the circadian rhythm system playing a crucial role. This chronobiological study investigated diurnal variations in exercise-induced hemodynamic changes in the common carotid artery. In a randomized crossover trial, twenty-two sedentary adults completed eight AE interventions (one per laboratory visit day), with each session performed at one of eight evenly distributed time points (from 06:00 to 20:00). Vascular ultrasound imaging and hemodynamic parameter calculations were performed both pre- and post-exercise. Compared to other time points, AE at 06:00 and 18:00 induced a greater and more sustained increase in mean flow rate and wall shear stress (WSS). Moreover, AE at 06:00 was associated with a smaller increase in oscillatory shear index and a larger decrease in peripheral resistance compared to other time points. Exercise-induced hemodynamic responses exhibited significant temporal variations. These findings emphasize the importance of exercise timing in optimizing vascular benefits for sedentary individuals.
有氧运动（AE）通过血流动力学反应调节血管功能，从而影响心血管健康和风险，昼夜节律系统在其中起着关键作用。这项时间生物学研究调查了运动诱导的颈总动脉血流动力学变化的昼夜差异。在一项随机交叉试验中，22名久坐不动的成年人完成了8次AE干预（每次实验室访问日进行一次），每次训练在8个均匀分布的时间点之一（从06:00至20:00）进行。在运动前后均进行了血管超声成像和血流动力学参数计算。与其他时间点相比，06:00和18:00进行的AE导致平均流速和壁面切应力（WSS）有更大且更持续的增加。此外，与其他时间点相比，06:00进行的AE与振荡剪切指数的较小增加和外周阻力的较大降低相关。运动诱导的血流动力学反应表现出显著的时间差异。这些发现强调了运动时间对于久坐不动的个体优化血管益处的重要性。
