Suppr超能文献

冠状病毒中的重组模式。

Patterns of Recombination in Coronaviruses.

作者信息

Soares Ricardo, Vieira Cristina P, Vieira Jorge

机构信息

Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.

Instituto de Biologia Molecular e Celular (IBMC), Rua Alfredo Allen 208, 4200-135 Porto, Portugal.

出版信息

Int J Mol Sci. 2025 Jun 11;26(12):5595. doi: 10.3390/ijms26125595.

Abstract

By bringing together different variant combinations, recombination can contribute to adaptation in species, some of which infect humans, and have given rise to epidemics and a pandemic. Therefore, in this work, the impact of the use of different recombination inference methods and sample sizes is addressed using data from 21 species, and recombination inferences are further supported using a phylogenetic approach. Recombination patterns are shown not to vary greatly between species. A positive correlation is found between gene position and recombination rates, suggesting intrinsic variation in recombination rates along the genome. Within and between species recombination patterns are shown to differ, the module type being the most prevalent between species except for the and genes, whose products are known to interact and thus must co-evolve, explaining why the two genes are often recombined as one unit. It is also shown that within species, the module type is prevalent for the gene only. Moreover, a positive correlation between recombination and selection is here reported. Therefore, intratypic recombination patterns are also shaped by selection. Recombination may thus be an important source of variability upon which selection can act.

摘要

通过汇集不同的变异组合,重组可以促进物种的适应性,其中一些物种会感染人类,并引发了流行病和大流行。因此,在这项工作中,我们使用来自21个物种的数据来探讨不同重组推断方法和样本量的使用所产生的影响,并使用系统发育方法进一步支持重组推断。结果表明,不同物种之间的重组模式差异不大。基因位置与重组率之间存在正相关,这表明沿着基因组的重组率存在内在变异。物种内部和物种之间的重组模式存在差异,除了已知其产物相互作用并因此必须共同进化的 和 基因外,模块类型在物种之间最为普遍,这解释了为什么这两个基因经常作为一个单元进行重组。研究还表明,在物种内部,模块类型仅在 基因中普遍存在。此外,本文报道了重组与选择之间的正相关。因此,选择也塑造了型内重组模式。重组可能是选择作用的重要变异来源。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验