来自意大利的须癣毛癣菌VII型菌株PG12DES的基因组特征分析。

Genome characterization of Trichophyton mentagrophytes genotype VII strain PG12DES from Italy.

作者信息

Rossi Luca, Sorrentino Annarita, Signoretto Prof Caterina, Gaibani Paolo

机构信息

Department of Diagnostic and Public Health, Microbiology Section, Verona University, Verona, Italy.

Microbiology and Virology Unit, Azienda Ospedaliera Universitaria Integrata Di Verona, Verona, Italy.

出版信息

Med Mycol. 2025 Jun 5;63(6). doi: 10.1093/mmy/myaf054.

DOI:10.1093/mmy/myaf054

PMID:40577043

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12203899/

Abstract

We characterized the genome of the clinical Trichophyton mentagrophytes genotype VII strain PG12DES. PG12DES genome harbored different virulence factors, including MEP-1, MEP-2, MEP-3, MEP-4, SUB-6, and ZAF-A. Phylogenetic analysis revealed that PG12DES was clonally related to a T. mentagrophytes strain isolated in Moldova in 2017. This study provides the genome characterization of a clinical strain from Italy and broadens the knowledge of the emergent genotype VII.

摘要

我们对临床须癣毛癣菌基因型VII菌株PG12DES的基因组进行了表征。PG12DES基因组含有不同的毒力因子，包括MEP-1、MEP-2、MEP-3、MEP-4、SUB-6和ZAF-A。系统发育分析表明，PG12DES与2017年在摩尔多瓦分离出的一株须癣毛癣菌菌株存在克隆相关性。本研究提供了来自意大利的一株临床菌株的基因组特征，并拓宽了对新出现的基因型VII的认识。