Lamotrigine-Induced Toxic Epidermal Necrolysis (Lyell's Syndrome): A Case Report and Literature Review.

Lyell's syndrome, also known as toxic epidermal necrolysis (TEN), is a rare and severe adverse drug reaction characterized by widespread skin detachment, mucosal involvement, and high mortality. We present the case of a 24-year-old female who developed TEN after the recent initiation of lamotrigine for bipolar disorder. The patient exhibited rapidly progressing skin blistering and detachment affecting over 30% of the body surface area, along with mucosal lesions. Lamotrigine was immediately discontinued, and the patient received intensive supportive treatment in a specialized care unit, resulting in a favorable recovery. This case emphasizes the importance of early recognition of TEN and immediate withdrawal of the offending agent. It also highlights the need for heightened clinical awareness when prescribing lamotrigine, especially during the initial titration phase. We aim to contribute to the growing literature on lamotrigine-induced TEN and underline the value of timely diagnosis and multidisciplinary management in improving patient outcomes.