Anastasi F, Di Nota C, Sessi S, Marzetti A, Sambito A, Della Casa M, Pizzolante S, Bandiera G
Unit of Otorhinolaryngology, Medical and Surgical Rhinology, Ospedale San Giovanni Evangelista, Tivoli, Italy.
Department Faculty of Medicine, Unicamillus-Saint Camillus International University of Health and Medical Sciences, Rome, Italy.
Front Allergy. 2025 Jun 16;6:1573764. doi: 10.3389/falgy.2025.1573764. eCollection 2025.
Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a chronic inflammatory disease. Its severe uncontrolled form may share, with asthma and atopic dermatitis, the pathophysiological mechanism of T helper 2 inflammation, characterized by tissue eosinophilia and high local IgE levels. Comorbidities and the severity of symptoms result in a poor quality of life. CRSwNP is difficult to treat both medically and surgically. Systemic corticosteroids are widely used to manage signs and symptoms of this disease. However, prolonged use of systemic corticosteroids is associated with numerous side effects that limit their long-term use. Alternative therapy with new biologic drugs allows good control of the signs and symptoms of CRSwNP, without the side effects of systemic corticosteroids. Through an interview proposed to patients affected by CRSwNP, the use of systemic corticosteroids, their dosage and the methods of administration were analyzed in the period preceding the start of therapy with biological drugs and the real impact of biological therapy on corticosteroid use.
伴鼻息肉的慢性鼻-鼻窦炎（CRSwNP）是一种慢性炎症性疾病。其严重的失控形式可能与哮喘和特应性皮炎一样，具有以组织嗜酸性粒细胞增多和局部IgE水平升高为特征的辅助性T细胞2炎症的病理生理机制。合并症和症状的严重程度导致生活质量较差。CRSwNP在药物治疗和手术治疗方面都很困难。全身用皮质类固醇被广泛用于控制这种疾病的体征和症状。然而，长期使用全身用皮质类固醇会带来许多副作用，限制了它们的长期使用。使用新型生物药物进行替代治疗可以很好地控制CRSwNP的体征和症状，而没有全身用皮质类固醇的副作用。通过对受CRSwNP影响的患者进行访谈，分析了在开始生物药物治疗之前的时间段内全身用皮质类固醇的使用情况、剂量和给药方法，以及生物治疗对皮质类固醇使用的实际影响。
