基于反苯环丙胺的赖氨酸特异性去甲基化酶1（LSD1）抑制剂作为降低……活力的有效药物
Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of .
作者信息
Fabbrizi Emanuele, Hailu Gebremedhin Solomon, Ganesan A, Fioravanti Rossella, Zwergel Clemens, Lambona Chiara, Valente Sergio, Fianco Giulia, Iuzzolino Angela, Trisciuoglio Daniela, Caroli Jonatan, Mattevi Andrea, Häberli Cécile, Keiser Jennifer, Rotili Dante, Mai Antonello
机构信息
Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
School of Pharmacy, Mekelle University, Mekelle 0231, Ethiopia.
出版信息
ACS Infect Dis. 2025 Aug 8;11(8):2178-2189. doi: 10.1021/acsinfecdis.5c00224. Epub 2025 Jul 2.
infections remain a major public health issue mainly in tropical and subtropical regions. While Praziquantel is the primary treatment for schistosomiasis, its limitations include resistance development and poor efficacy against juvenile worms. Given the biological similarities between tumor and parasite-infected cells, LSD1 inhibitors─primarily explored as anticancer agents─have been investigated for their antiparasitic potential.
感染仍然是一个主要的公共卫生问题，主要集中在热带和亚热带地区。虽然吡喹酮是治疗血吸虫病的主要药物，但其局限性包括产生耐药性以及对幼虫的疗效不佳。鉴于肿瘤细胞和寄生虫感染细胞之间存在生物学相似性，主要作为抗癌药物进行研究的赖氨酸特异性去甲基化酶1（LSD1）抑制剂已被研究其抗寄生虫潜力。
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