新冠病毒疾病急性期和急性后期的线粒体功能障碍与非传染性疾病风险
Mitochondrial dysfunction in acute and post-acute phases of COVID-19 and risk of non-communicable diseases.
作者信息
Madsen Helena Borland, Durhuus Jon Ambæk, Andersen Ove, Straten Per Thor, Rahbech Anne, Desler Claus
机构信息
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Research, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, 2650, Copenhagen, Denmark.
出版信息
NPJ Metab Health Dis. 2024 Dec 4;2(1):36. doi: 10.1038/s44324-024-00038-x.
The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and post-acute phases of COVID-19, highlighting its impact on various organs and its potential role in the development of non-communicable diseases (NCDs). We discuss how SARS-CoV-2 directly affects mitochondrial function and the role of the virus-induced immune response in exacerbating mitochondrial impairment. This review highlights the critical role of mitochondria in COVID-19 pathogenesis and the importance of addressing mitochondrial health to mitigate acute and chronic effects of the disease.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）大流行已导致广泛的发病和死亡，很大一部分受影响人群出现长期健康并发症。本综述探讨了COVID-19急性期和急性后期线粒体功能障碍的机制，强调了其对各个器官的影响及其在非传染性疾病（NCDs）发展中的潜在作用。我们讨论了SARS-CoV-2如何直接影响线粒体功能以及病毒诱导的免疫反应在加剧线粒体损伤中的作用。本综述强调了线粒体在COVID-19发病机制中的关键作用以及解决线粒体健康问题以减轻该疾病急性和慢性影响的重要性。
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