She Yumo, Liu He, Yuan Hailiang, Li Yiqi, Liu Xunjie, Liu Ruonan, Wang Mengyao, Wang Tingting, Wang Lina, Liu Meihan, Wan Wenyu, Tian Ye, Zhang Kai
Department of Gastroenterology, Endoscopic Center, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, 110169, People's Republic of China.
Nanomicro Lett. 2025 Jul 3;17(1):319. doi: 10.1007/s40820-025-01834-w.
Refractory wounds cause significant harm to the health of patients and the most common treatments in clinical practice are surgical debridement and wound dressings. However, certain challenges, including surgical difficulty, lengthy recovery times, and a high recurrence rate persist. Conductive hydrogel dressings with combined monitoring and therapeutic properties have strong advantages in promoting wound healing due to the stimulation of endogenous current on wounds and are the focus of recent advancements. Therefore, this review introduces the mechanism of conductive hydrogel used for wound monitoring and healing, the materials selection of conductive hydrogel dressings used for wound monitoring, focuses on the conductive hydrogel sensor to monitor the output categories of wound status signals, proving invaluable for non-invasive, real-time evaluation of wound condition to encourage wound healing. Notably, the research of artificial intelligence (AI) model based on sensor derived data to predict the wound healing state, AI makes use of this abundant data set to forecast and optimize the trajectory of tissue regeneration and assess the stage of wound healing. Finally, refractory wounds including pressure ulcers, diabetes ulcers and articular wounds, and the corresponding wound monitoring and healing process are discussed in detail. This manuscript supports the growth of clinically linked disciplines and offers motivation to researchers working in the multidisciplinary field of conductive hydrogel dressings.
难治性伤口对患者健康造成重大危害,临床实践中最常见的治疗方法是手术清创和伤口敷料。然而,包括手术难度大、恢复时间长和复发率高等挑战依然存在。具有监测与治疗相结合特性的导电水凝胶敷料,因其对伤口内源性电流的刺激,在促进伤口愈合方面具有强大优势,是近期进展的重点。因此,本综述介绍了用于伤口监测和愈合的导电水凝胶的作用机制、用于伤口监测的导电水凝胶敷料的材料选择,重点关注导电水凝胶传感器监测伤口状态信号的输出类别,这对于无创、实时评估伤口状况以促进伤口愈合具有重要价值。值得注意的是,基于传感器数据的人工智能(AI)模型预测伤口愈合状态的研究,AI利用这些丰富的数据集来预测和优化组织再生轨迹并评估伤口愈合阶段。最后,详细讨论了包括压疮、糖尿病溃疡和关节伤口在内的难治性伤口以及相应的伤口监测和愈合过程。本手稿支持临床相关学科的发展,并为从事导电水凝胶敷料多学科领域研究的人员提供动力。