Wang Zhen, Hu Hanwen, Bao Yunjia, Pang Liwei, Yang Chenghui
Department of Breast Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Cancer Biol Med. 2025 Jul 2;22(6):598-617. doi: 10.20892/j.issn.2095-3941.2025.0023.
Neutrophils are the protagonists of the host immune response, possessing potent antimicrobial and inflammatory capacities. The neutrophil reservoir as well as the development, mobilization, chemotaxis, pro-inflammatory activity, and clearance of neutrophils are strictly regulated to prevent inflammation-induced tissue damage. Inflammation pervades almost every type of cancer. However, there is growing awareness that although the tumor microenvironment has the capacity to recruit neutrophils, the functions are diverse and include roles other than that of sentinels in cancer. This review highlights the heterogeneity of neutrophils in tumors, discusses the dual role of neutrophils as angels and demons in tumorigenesis, invasion, and metastasis, and examines the potential of neutrophils as targets in clinical therapy.
中性粒细胞是宿主免疫反应的主角，具有强大的抗菌和炎症能力。中性粒细胞库以及中性粒细胞的发育、动员、趋化性、促炎活性和清除过程都受到严格调控，以防止炎症引起的组织损伤。炎症几乎渗透到每一种癌症类型中。然而，人们越来越意识到，尽管肿瘤微环境有能力招募中性粒细胞，但其功能是多样的，在癌症中的作用不仅仅是充当哨兵。这篇综述强调了肿瘤中中性粒细胞的异质性，讨论了中性粒细胞在肿瘤发生、侵袭和转移中作为天使和恶魔的双重作用，并探讨了将中性粒细胞作为临床治疗靶点的潜力。
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