Altered model-based prediction error signaling in the lateral orbitofrontal cortex in patients with obsessive-compulsive disorder: An fMRI study.

BACKGROUND

Compared to healthy individuals, patients with obsessive-compulsive disorder (OCD) are found to rely more on model-free decision-making strategies which may underlie symptom expression. It is, however, unclear whether these behavioral differences are represented in neural alterations of model-free and model-based decision-making when tested simultaneously.

METHODS

We investigated the neural signatures of 22 OCD patients and 22 matched controls who completed a two-step Markov decision-making task during functional MRI scanning. We used hierarchical Bayesian modelling and Bayesian statistics to examine model-based and model-free decision-making behaviors. Parametric regressors were employed for model-free and model-based reward prediction errors to inform neural reward presentation, which we analyzed using a Bayesian Multilevel Modeling (BML) approach. Associations between significant activations and symptoms as well as cognitive scores were explored using Bayesian linear regression.

RESULTS

While controls received significantly more rewards and were significantly less stochastic compared to patients, both groups similarly relied on model-free decision-making strategies. Importantly, our group comparison of neural reward prediction error responses showed greater activation for model-based reward prediction error in the lateral orbitofrontal cortex (lateral OFC) in OCD patients compared to controls, but no differences for model-free reward prediction error processing. Increased lateral OFC activity was associated with lower obsessive symptoms and better cognitive functioning.

CONCLUSION

These findings support the notion that OCD is associated with an altered goal-directed system, which may be expressed through increased activation in the lateral OFC activity underlying goal-directed behavior. Importantly, the hyperactivity observed in this region was linked to reduced obsessive symptoms and improved cognitive functioning, potentially indicating compensatory mechanisms and highlighting the lateral OFC as a potential target for future interventions.