从尼日利亚拉各斯一名患有败血症的新生儿中分离出的多重耐药菌株AH1-NIMR的基因组分析
Genomic Analysis of Multidrug Resistant Strain AH1-NIMR Isolated from a Neonate with Sepsis in Lagos, Nigeria.
作者信息
Seriki Abiodun Tola, Obi Chioma, Olashile Amusa Azeez, Essiet Utibeima Udo, Akingboye Desmond Wemimo, Ajayi Abraham, Gladys Egwuatu Tenny Obiageli, Smith Stella
机构信息
Department of Biological Sciences, College of Natural and Applied Sciences, Bells University of Technology, Ota, Ogun State, Nigeria.
Department of Molecular Biology and Biotechnology, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.
出版信息
Infect Chemother. 2025 Jun;57(2):316-320. doi: 10.3947/ic.2025.0040.
has emerged as a major bacterial pathogen implicated in neonatal sepsis, with several strains acquiring resistance to commonly used antibiotics. In this study, we provide the antibiotic resistance profile and genomic analysis of a multidrug-resistant AH1-NIMR isolated from a neonate presenting with sepsis in a tertiary hospital in Lagos, Nigeria. AH1-NIMR was resistant to ten of twelve antibiotics that were tested. Whole-genome sequencing and bioinformatics analysis revealed that the isolate harboured several antimicrobial resistance determinants, including plasmids IncHI2-1 and Col(pHAD28). Enhanced surveillance and screening for in sepsis cases are recommended.
已成为新生儿败血症中涉及的主要细菌病原体，有几种菌株对常用抗生素产生了耐药性。在本研究中，我们提供了从尼日利亚拉各斯一家三级医院一名患有败血症的新生儿中分离出的多重耐药AH1-NIMR的抗生素耐药谱和基因组分析。AH1-NIMR对所测试的十二种抗生素中的十种耐药。全基因组测序和生物信息学分析表明，该分离株含有多种抗菌耐药决定因素，包括IncHI2-1和Col(pHAD28)质粒。建议加强对败血症病例的监测和筛查。
Zotero 插件