树突状细胞生物学：健康与疾病状态下的情况

The Biology of Dendritic Cells: In Health and Disease.

作者信息

Royzman Dmytro, Dörrie Jan, Heiß Anita, Sinner Pia, Peckert-Maier Katrin, Schaft Niels, Sadeghi Shermeh Atefeh, Strack Astrid, Wild Andreas, Steinkasserer Alexander

机构信息

Department of Immune Modulation, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Department of Dermatology, Universtitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

出版信息

Adv Exp Med Biol. 2025;1476:1-30. doi: 10.1007/978-3-031-85340-1_1.

DOI:10.1007/978-3-031-85340-1_1

PMID:40622537

Abstract

Dendritic cells (DCs) are crucial players within the immune system and are therefore abundant throughout the body. To achieve the variety of highly specialized DC subsets found in mammals, DC progenitor cells undergo a complex process of development and differentiation. The first divergence of different DC lineages occurs already during embryonic development, when Langerhans cells (LCs) are established by fetal liver hematopoiesis. Meanwhile, hematopoietic stem cells (HSCs) in the bone marrow give rise to DCs populating the blood and lymphoid organs. This chapter will provide an overview of both developmental pathways, distinguishing surface markers and key transcription factors.

摘要

树突状细胞（DCs）是免疫系统中的关键参与者，因此在全身广泛存在。为了形成哺乳动物中发现的各种高度特化的DC亚群，DC祖细胞经历了一个复杂的发育和分化过程。不同DC谱系的首次分化在胚胎发育期间就已发生，此时胎儿肝脏造血产生朗格汉斯细胞（LCs）。与此同时，骨髓中的造血干细胞（HSCs）产生分布于血液和淋巴器官的DCs。本章将概述这两种发育途径、区分表面标志物和关键转录因子。