作为致癌物的霉菌毒素。

Mycotoxins as carcinogens.

作者信息

Hussain A M

出版信息

Basic Life Sci. 1985;34:87-96. doi: 10.1007/978-1-4684-4976-1_8.

Abstract

Fungi which contaminate food and feed products produce toxic metabolites under favourable conditions, thus posing a serious health problem. A variety of mycotoxins are produced by different fungi, but aflatoxins have been investigated more extensively. Varied reports are available on the production of aflatoxins by different species of Aspergillus and Penicillium; however, A. flavus and A. parasiticus have the greatest capacity and appear to be the primary sources of aflatoxins. Preformed mycotoxins are ingested by man through the consumption of vegetable and animal products (milk, meat, etc.). Factors affecting toxicity include species, age, sex, and nutrition. Evidence from animal experiments provides enough information to indicate that most of the mycotoxins are carcinogens.

摘要

污染食品和饲料产品的真菌在适宜条件下会产生有毒代谢产物，从而造成严重的健康问题。不同真菌会产生多种霉菌毒素，但黄曲霉毒素受到的研究更为广泛。关于不同种类曲霉和青霉产生黄曲霉毒素的报道多种多样；然而，黄曲霉和寄生曲霉产生黄曲霉毒素的能力最强，似乎是黄曲霉毒素的主要来源。人体通过食用植物和动物产品（牛奶、肉类等）摄入预先形成的霉菌毒素。影响毒性的因素包括物种、年龄、性别和营养状况。动物实验的证据提供了足够的信息表明，大多数霉菌毒素都是致癌物。