垂体功能减退与非酒精性脂肪性肝病之间的病理生理机制。
The pathophysiological mechanism between hypopituitarism and nonalcoholic fatty liver disease.
作者信息
Zhang Xinhe, Tian Haoyu, Li Yiling
机构信息
Gastroenterology Department, The First Affiliated Hospital of China Medical University, No.155 North Nanjing Street, Heping District, Shenyang 110001, Liaoning, China.
The 3rd Clinical Department of China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning, China.
出版信息
ILIVER. 2022 Mar 10;1(1):65-71. doi: 10.1016/j.iliver.2022.02.004. eCollection 2022 Mar.
Nonalcoholic fatty liver disease (NAFLD) is a common chronic metabolic liver disease worldwide. It is closely related to diseases of the cardiovascular system and chronic kidney disease. It can also occur secondary to many other diseases. Current research shows that patients with hypopituitarism have a high risk of developing NAFLD. After the adenohypophysis is dominated by hypothalamic hormones, hormones are secreted to act on the corresponding tissues or organs. It is characterized by a decrease in the thyroid hormone, cortisol, and growth hormone levels. In this review, we analyzed the mechanisms related to NAFLD through thyroid secretion, growth hormone secretion, sex hormone, and prolactin axes in patients with hypopituitarism, which will provide information and a theoretical basis for clinical diagnosis and treatment.
非酒精性脂肪性肝病（NAFLD）是全球常见的慢性代谢性肝病。它与心血管系统疾病和慢性肾脏病密切相关。它也可继发于许多其他疾病。目前的研究表明，垂体功能减退患者发生NAFLD的风险很高。腺垂体受下丘脑激素支配后，分泌激素作用于相应的组织或器官。其特征是甲状腺激素、皮质醇和生长激素水平降低。在本综述中，我们通过垂体功能减退患者的甲状腺分泌、生长激素分泌、性激素和催乳素轴分析了与NAFLD相关的机制，这将为临床诊断和治疗提供信息和理论依据。
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