宏转录组学捕捉到肠道微生物的活动。
Metatranscriptomics catches gut microbes in the act.
作者信息
Liu Kailin, Wang Yuhao
机构信息
Zhejiang Provincial Key Laboratory of Pancreatic Disease of The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China.
Zhejiang Provincial Key Laboratory of Pancreatic Disease of The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, Zhejiang 310029, China.
出版信息
Cell Host Microbe. 2025 Jul 9;33(7):1040-1042. doi: 10.1016/j.chom.2025.06.004.
In this issue of Cell Host & Microbe, Flores Ramos et al. employ metatranscriptomics to uncover diurnal microbial functional shifts in the gut microbiome driven by time-restricted feeding. Their work highlights the value of metatranscriptomics over metagenomics in capturing real-time microbial activity and guiding therapeutic bacterial engineering.
在本期《细胞宿主与微生物》杂志中，弗洛雷斯·拉莫斯等人运用宏转录组学来揭示限时进食驱动下肠道微生物群的昼夜微生物功能变化。他们的研究突出了宏转录组学相对于宏基因组学在捕捉实时微生物活性以及指导治疗性细菌工程方面的价值。
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