Zhang Liwen, Zhao Jinhong, Zhang Jie, Lou Bang, Li Huijie, Guo Fangyuan, Yang Gensheng, Hong Weiyong
Department of Pharmacy, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310051, People's Republic of China.
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China.
Sci Rep. 2025 Jul 10;15(1):24892. doi: 10.1038/s41598-025-09748-8.
The convergence of advanced materials science and additive manufacturing technologies has revolutionized medical applications ranging from orthodontic devices to patient-specific bone fixation systems. Despite these advancements, the clinical translation of 3D-printed orthopedic implants remains constrained by suboptimal biocompatibility of conventional manufacturing materials. This study systematically evaluates dental resin-based composites as alternative biomaterials for bone fixation devices, hypothesizing that their rapid photopolymerization kinetics, mechanical robustness, and inherent biocompatibility can address current limitations. Through stereolithography technology, ceftriaxone sodium-loaded bone fixation devices were developed with customized geometries tailored to diverse anatomical requirements. Material optimization revealed that a 7:3 ratio of ethoxylated bisphenol A dimethacrylate (BPA2EODMA) to triethylene glycol dimethacrylate (TEGDMA) achieved optimal mechanical performance. Cytocompatibility assessment using L929 fibroblasts demonstrated > 70% cell viability, confirming minimal cytotoxicity. The drug-eluting implants exhibited potent antimicrobial efficacy in 8-h elution assays, showing inhibition rates of 49.14 ± 4.89% (Staphylococcus aureus), 48.38 ± 5.88% (Escherichia coli), and 26.79 ± 2.69% (Candida albicans). These results validate the dual functionality of antibiotic-loaded dental resin constructs, positioning them as promising candidates for patient-specific orthopedic solutions that simultaneously address mechanical stability, osseointegration, and infection prevention.
先进材料科学与增材制造技术的融合彻底改变了从正畸器械到个性化骨固定系统等一系列医学应用。尽管取得了这些进展，但3D打印骨科植入物的临床转化仍受到传统制造材料生物相容性欠佳的限制。本研究系统评估了牙科树脂基复合材料作为骨固定装置的替代生物材料，推测其快速光聚合动力学、机械强度和固有的生物相容性能够解决当前的局限性。通过立体光刻技术，开发出了载有头孢曲松钠的骨固定装置，其定制的几何形状适合各种解剖学需求。材料优化表明，乙氧基化双酚A二甲基丙烯酸酯（BPA2EODMA）与三乙二醇二甲基丙烯酸酯（TEGDMA）的比例为7:3时可实现最佳机械性能。使用L929成纤维细胞进行的细胞相容性评估显示细胞活力>70%，证实细胞毒性极小。药物洗脱植入物在8小时洗脱试验中表现出强大的抗菌效果，对金黄色葡萄球菌的抑制率为49.14±4.89%，对大肠杆菌的抑制率为48.38±5.88%，对白色念珠菌的抑制率为26.79±2.69%。这些结果验证了载抗生素牙科树脂构建体的双重功能，使其成为个性化骨科解决方案的有希望的候选者，可同时解决机械稳定性、骨整合和感染预防问题。
