Vosoughi Fardis, Vahedi Pouya, Nakhjiri Mobina Taghva, Keyhani Sohrab, Soleymanha Mehran, LaPrade Robert, Tollefson Luke V, Oskouie Iman Menbari
Department of Orthopaedic and Trauma Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Knee Surg Sports Traumatol Arthrosc. 2025 Sep;33(9):3361-3374. doi: 10.1002/ksa.12796. Epub 2025 Jul 18.
High tibial osteotomy (HTO) is a cornerstone treatment for medial compartment osteoarthritis (OA) in active patients with varus deformity. However, managing the combination of varus alignment and the medial meniscus posterior root tears (MMPRT) remains controversial. The purpose of this systematic review was to synthesise data from recent comparative studies and evaluate whether adding an MMPRT repair to an HTO enhances outcomes, particularly with respect to meniscal healing, cartilage preservation, and patient function.
We systematically searched MEDLINE, Embase, Scopus, and Web of Science through April 2025 for studies comparing isolated HTO with HTO plus MMPRT repair. Outcomes included meniscal healing, cartilage status, and patient-reported measures. Risk of bias was assessed using ROBINS-I.
Six studies (506 knees) were included, with 260 undergoing HTO plus MMPRT repair. The reported mean difference in complete meniscus healing ranged from 12.5% to 40% in the HTO plus MMPRT repair group, while it ranged from 0% to 15% in the isolated HTO group. Joint space width (JSW) was reported in three studies, with one study reporting a significant improvement in the HTO plus MMPRT repair group. Cartilage outcomes were superior in three of six studies. One study reported significant functional improvement with a concomitant repair. Despite methodological heterogeneity, all studies had a moderate risk of bias.
While short-term subjective outcomes were similar between isolated HTO and HTO plus MMPRT repair, objective measures, namely higher meniscal healing rates and more stable cartilage scores, consistently favoured the combined approach. In the younger population, even short-term subjective outcomes showed significant improvements along with objective measures and return to sports. Long-term clinical trials are required to determine if these biological advantages translate into a delay in the progression of knee osteoarthritis, particularly in younger, active patients.
Level III, systematic review.
高位胫骨截骨术(HTO)是治疗伴有内翻畸形的活跃患者内侧间室骨关节炎(OA)的基石性治疗方法。然而,处理内翻畸形与内侧半月板后根撕裂(MMPRT)并存的情况仍存在争议。本系统评价的目的是综合近期比较研究的数据,评估在HTO基础上加用MMPRT修复是否能改善疗效,特别是在半月板愈合、软骨保留和患者功能方面。
我们系统检索了截至2025年4月的MEDLINE、Embase、Scopus和Web of Science数据库,以查找比较单纯HTO与HTO联合MMPRT修复的研究。结局指标包括半月板愈合情况、软骨状态和患者报告的测量指标。使用ROBINS - I评估偏倚风险。
纳入6项研究(共506膝),其中260膝接受了HTO联合MMPRT修复。HTO联合MMPRT修复组报告的完全半月板愈合的平均差异范围为12.5%至40%,而单纯HTO组为0%至15%。三项研究报告了关节间隙宽度(JSW),其中一项研究报告HTO联合MMPRT修复组有显著改善。六项研究中有三项软骨结局更好。一项研究报告联合修复后功能有显著改善。尽管方法存在异质性,但所有研究的偏倚风险均为中度。
虽然单纯HTO与HTO联合MMPRT修复的短期主观结局相似,但客观指标,即更高的半月板愈合率和更稳定的软骨评分,始终支持联合治疗方法。在年轻人群中,即使是短期主观结局也显示出与客观指标一起有显著改善且能恢复运动。需要进行长期临床试验来确定这些生物学优势是否能延缓膝关节骨关节炎的进展,特别是在年轻、活跃的患者中。
三级,系统评价。