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扁平苔藓性唇炎:简要综述

Lichen Planus Cheilitis: A Brief Review.

作者信息

Garg Sonika, Behera Biswanath, Gowda Shreya K, Thakur Vishal, Sethy Madhusmita, Ayyanar Pavithra

机构信息

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Department of Pathology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

出版信息

Indian Dermatol Online J. 2025 Jun 27;16(4):539-544. doi: 10.4103/idoj.idoj_672_24. eCollection 2025 Jul-Aug.

Abstract

Cheilitis encompasses a spectrum of inflammatory conditions affecting the lips, with etiologies ranging from benign habits to malignant transformations. Lichen planus (LP) cheilitis is a rare variant, often misdiagnosed due to its resemblance to other lip dermatoses, particularly in individuals with skin of color. This review summarised the current literature, including case series and reports, focusing on the clinical presentation, diagnostic modalities, differential diagnosis, treatment options, course, and prognosis of LP cheilitis. LP cheilitis predominantly affects the lower lip and may present in isolation or alongside mucocutaneous LP. The erosive variant is the most common morphology, often accompanied by Wickham's striae observed on dermoscopy. Histopathological findings mirror those of cutaneous LP, and immunofluorescence may reveal shaggy fibrinogen deposits. Management involves topical corticosteroids and calcineurin inhibitors, with systemic agents reserved for recalcitrant cases. Photoprotection is essential due to the risk of malignant transformation. In conclusion, LP cheilitis is a distinct but underrecognized entity requiring tailored clinical and histopathological evaluation. Enhanced awareness and large-scale studies, especially inclusive of diverse skin types, are crucial for improving diagnostic accuracy and therapeutic outcomes.

摘要

唇炎包括一系列影响唇部的炎症性疾病,其病因范围从良性习惯到恶性转变。扁平苔藓(LP)性唇炎是一种罕见的类型,由于其与其他唇部皮肤病相似,尤其是在有色人种个体中,常被误诊。本综述总结了当前的文献,包括病例系列和报告,重点关注LP性唇炎的临床表现、诊断方法、鉴别诊断、治疗选择、病程和预后。LP性唇炎主要累及下唇,可单独出现或与黏膜皮肤型LP同时出现。糜烂型是最常见的形态,在皮肤镜检查时通常伴有威克姆纹。组织病理学表现与皮肤型LP相似,免疫荧光检查可能显示粗乱的纤维蛋白原沉积。治疗包括外用糖皮质激素和钙调神经磷酸酶抑制剂,全身用药仅用于难治性病例。由于存在恶性转变的风险,防晒至关重要。总之,LP性唇炎是一种独特但未得到充分认识的疾病,需要进行针对性的临床和组织病理学评估。提高认识和开展大规模研究,尤其是纳入不同皮肤类型的研究,对于提高诊断准确性和治疗效果至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c11/12270428/b5feed12de0b/IDOJ-16-539-g001.jpg

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